A study for the generation mechanism and physiological relevance of left-right asymmetry of the brain

大脑的不对称性是如何产生的？大脑不对称性在高级大脑功能中的意义是什么？为了解决这些基本问题，我们使用几种突变小鼠进行了电生理和行为研究。我们发现，一种已知在细胞免疫中很重要的蛋白质对于大脑中不对称神经元回路的产生至关重要。缺乏这种蛋白质的转基因小鼠在空间记忆的保持方面表现出缺陷。

How is brain asymmetry generated? What is the meaning of brain asymmetry in higher-order brain functions? To address these fundamental questions, we conducted electrophysiological and behavioral studies using several strains of mutant mice. We found that a protein, known to be important in cellular immunity, was critical for the generation of asymmetrical neuronal circuitry in the brain. The transgenic mice lacking this protein showed deficits in the retention of spatial memory.