Role of Keap1/Nrf2 system in host defense against acute lung injury.

Keap1/Nrf2 系统在宿主防御急性肺损伤中的作用。

• 批准号: 20590911
• 负责人: ISHII Yukio
• 金额: $ 3万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590911/
• 关键词: Nrf2; Keap1; 酸化ストレス; 急性肺傷害; マクロファージ; 転写因子; 肺線維症; Th1/Th2; Th1; Th2; 敗血症; 急性呼吸促迫症候群; リポ多糖体; Toll様受容体

In the present study, we investigated the role of Nrf2 in protection against the development of acute lung injury. Mice lacking Nrf2 were susceptible to acute lung injury induced by several stimuli, such as bleomycin, lipopolysaccaride, and influenza virus. The induction of several self-defense genes was lower in the lungs of Nrf2-deficient mice than in wild-type mice. Activation of nuclear factor-κB and induction of proinflammatory cytokines were significantly higher in Nrf2-deficient mice than in wild-type mice. Results indicate Nrf2 is a pivotal factor in protection against the development of acute lung injury induced by environmental stimuli.

在本研究中，我们研究了Nrf 2在预防急性肺损伤发展中的作用。缺乏Nrf 2的小鼠易受几种刺激诱导的急性肺损伤，如博来霉素、脂多糖和流感病毒。在Nrf 2缺陷小鼠的肺中，几种自卫基因的诱导低于野生型小鼠。核因子-κB的活化和促炎细胞因子的诱导在Nrf 2缺陷型小鼠中显著高于野生型小鼠。结果表明，Nrf 2是一个关键因素，在保护免受发展的急性肺损伤诱导的环境刺激。

项目成果

ARDSと活性酸素

ARDS 和活性氧

• 发表时间: 2010
• 期刊: 最新ARDSのすべて(別冊・医学のあゆみ)
• 作者: Kikuchi N;Ishii Y;Morishima Y;et al.;石井幸雄
• 通讯作者: 石井幸雄

Genetic ablation of Nrf2 exacerbates influenza virusinduced lung injury after cigarette smoke exposure in mice

Nrf2 的基因消除加剧了小鼠吸烟后流感病毒引起的肺损伤

• 发表时间: 2010
• 作者: Yageta Y;Kikuchi N;Ishii Y;et al.
• 通讯作者: et al.

転写因子T-betはブレオマイシン誘発肺線維症を抑制する

转录因子 T-bet 抑制博莱霉素诱导的肺纤维化

• 发表时间: 2010
• 作者: 菊池教大;石井幸雄;原口典博;他
• 通讯作者: 他

Role of Nrf2 in host defense against influenza in cigarette smoke-exposed mice

Nrf2 在香烟烟雾暴露小鼠宿主防御流感中的作用

• 发表时间: 2011
• 期刊: Journal of Virology
• 影响因子: 5.4
• 作者: Yageta Y;Ishii Y;et al.
• 通讯作者: et al.

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

• DOI: 10.1158/1078-0432.ccr-08-2822
• 发表时间: 2009-05-15
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Homma, Shinsuke;Ishii, Yukio;Yamamoto, Masayuki
• 通讯作者: Yamamoto, Masayuki