Investigation of cell polarity signal controlling organization of the actin cytoskeleton and membrane traffic

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Cell polarity is the most fundamental cue for controlling cellular function including cell morphogenesis and cell migration. Molecular mechanism engaged in this system is indispensible for the cell activity in not only high order life phenomenon such as human development and brain but also survival of unicellular organisms including yeast and protozoa. In this project, I aimed to reveal the molecular mechanism how cytoskeleton organization is established, how membrane transport is spatiotemporally regulated, and how those two important events are related under cell polarity signal. Finally, I have succeeded to find two novel signaling pathways controlling and connecting cytoskeleton organization and membrane traffic in the fission yeast Schizosaccharomyces pombe.