Study of GMF-based control of actin-meshwork organization during cell migration and endocytosis

Arp2/3诱导肌动蛋白网的形成，这是各种类型细胞运动中膜变形所必需的。激活Arp2/3功能的分子机制已被广泛研究。然而，在肌动蛋白细胞骨架的循环过程中，arp2 /3活性是如何下调的，几乎没有研究。因此，我决定研究胶质细胞成熟因子GMF的酵母同源物的分子功能。此外，我还尝试利用显示动态细胞行为的细胞模具来研究GmfA的细胞功能。

Arp2/3 induces formation of actin meshwork which is required for membrane deformation in various type of cell movements. It has well been studied the molecular machinery activating Arp2/3 function. However, there is almost no study how Arp2/3-activity is down regulated during recycling of the actin cytoskeleton. Therefore, I decided to study the molecular function of a yeast homologue of the glia maturation factor GMF. Moreover, I tried to investigate cellular function of GmfA by using cellular mold which shows dynamic cell behavior.