Roles of condensins in mammalian meiosis

点击翻译按钮获取中文摘要

I clarified the spatiotemporal dynamics of condensin I and condensin II during meiosis of mouse oocytes. In the assembly of bivalent chromosomes, both condensins are involved in chromosome condensation and segregation, and establishment of monopolar attachment of sister kinetochores in meiosis. In addition, I identified a new meiosis-specific cohesin subunit RAD21L. It is suggested that RAD21L might be involved in synapsis and recombination of homologous chromosomes from its specific expression in prophae I and its localization on the synaptonemal complex.