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Role of keratinocytes in the development of atopic dermatitis

Role of keratinocytes in the development of atopic dermatitis
角质形成细胞在特应性皮炎发生中的作用
批准号:
20780224
负责人:
OHMORI Keitaro
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
The importance of keratinocytes in the development of atopic dermatitis was evaluated by using a murine model of atopic dermatitis and dogs. We found that increased cell proliferation of keratinocytes and the local crosstalk between keratinocytes and mast cells in the skin were pivotal in the pathogenesis and clinical signs of atopic dermatitis. We also revealed that improvement of skin barrier function could be effective for alleviating atopic dermatitis and would be a local therapeutic option.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [大森啓太郎, 田中あかね, 巻田優花, 高井政貴, 吉成佑治, 松田浩珍]
通讯作者: 松田浩珍
DOI: 10.4049/jimmunol.0802870
发表时间: 2009-03-01
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者: [Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H]
通讯作者: Huang H
DOI: 10.1016/j.vetimm.2008.06.014
发表时间: 2008-11
期刊: Veterinary immunology and immunopathology
影响因子: 1.8
作者: [K. Ohmori;S. Kawarai;Nobutaka Yasuda;A. Tanaka;H. Matsuda;R. Nishimura;N. Sasaki;H. Tsujimoto;K. Masuda]
通讯作者: K. Ohmori;S. Kawarai;Nobutaka Yasuda;A. Tanaka;H. Matsuda;R. Nishimura;N. Sasaki;H. Tsujimoto;K. Masuda
A novel NF-κB inhibitor improves glucocorticoid 1 sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors
一种新型 NF-κB 抑制剂通过上调糖皮质激素受体的表达来提高犬肿瘤淋巴细胞的糖皮质激素 1 敏感性
DOI: --
发表时间: 2010
期刊: Research in Veterinary Science (in press)
影响因子: --
作者: [Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.]
通讯作者: Matsuda H.
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