Role of keratinocytes in the development of atopic dermatitis

角质形成细胞在特应性皮炎发生中的作用

• 批准号: 20780224
• 负责人: OHMORI Keitaro
• 金额: $ 2.75万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20780224/
• 关键词: アレルギー; 免疫; 炎症; 皮膚; 動物

The importance of keratinocytes in the development of atopic dermatitis was evaluated by using a murine model of atopic dermatitis and dogs. We found that increased cell proliferation of keratinocytes and the local crosstalk between keratinocytes and mast cells in the skin were pivotal in the pathogenesis and clinical signs of atopic dermatitis. We also revealed that improvement of skin barrier function could be effective for alleviating atopic dermatitis and would be a local therapeutic option.

通过使用特应性皮炎的小鼠模型和狗来评价角质形成细胞在特应性皮炎发展中的重要性。我们发现，角质形成细胞的细胞增殖和角质形成细胞和肥大细胞在皮肤中的局部串扰增加的发病机制和特应性皮炎的临床体征的关键。我们还发现，改善皮肤屏障功能可以有效地缓解特应性皮炎，并将是一个局部治疗的选择。

项目成果

イヌの痒みに対する高純度軟化水を用いたシャンプー療法の臨床的効果

高纯度软化水洗发疗法治疗犬瘙痒的临床效果

• 发表时间: 2009
• 作者: 大森啓太郎;田中あかね;巻田優花;高井政貴;吉成佑治;松田浩珍
• 通讯作者: 松田浩珍

Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells.

• DOI: 10.1016/j.vetimm.2008.06.014
• 发表时间: 2008-11
• 期刊: Veterinary immunology and immunopathology
• 影响因子: 1.8
• 作者: K. Ohmori;S. Kawarai;Nobutaka Yasuda;A. Tanaka;H. Matsuda;R. Nishimura;N. Sasaki;H. Tsujimoto;K. Masuda

IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen.

• DOI: 10.4049/jimmunol.0802870
• 发表时间: 2009-03-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Ohmori K;Luo Y;Jia Y;Nishida J;Wang Z;Bunting KD;Wang D;Huang H
• 通讯作者: Huang H

A novel NF-κB inhibitor improves glucocorticoid 1 sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors

一种新型 NF-κB 抑制剂通过上调糖皮质激素受体的表达来提高犬肿瘤淋巴细胞的糖皮质激素 1 敏感性

• 发表时间: 2010
• 期刊: Research in Veterinary Science (in press)
• 作者: Matsuda A;Tanaka A;Muto S;Ohmori K;Furusaka T;Jung K;Karasawa K;Okamoto N;Oida K;Itai A;Matsuda H.
• 通讯作者: Matsuda H.

高純度軟化水(UPSW)のアトピー性皮膚炎改善効果4. 皮膚バリア損傷モデルでの検証

高纯软化水（UPSW）改善特应性皮炎的效果4.皮肤屏障损伤模型的验证

• 发表时间: 2008
• 作者: 田中あかね;大森啓太郎;高井政貴;吉成佑治;松田浩珍
• 通讯作者: 松田浩珍