Development of novel therapeutic strategies and elucidation of mechanisms regulating allergic inflammation based on circadian rhythms

开发新的治疗策略并阐明基于昼夜节律的过敏性炎症调节机制

• 批准号: 23688040
• 负责人: OHMORI Keitaro
• 金额: $ 17.14万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23688040/
• 关键词: アレルギー; サーカディアンリズム; 動物モデル

Although allergic diseases have increased dramatically in recent years, effective therapy has yet to be established. The purpose of this study was to elucidate the mechanisms regulating allergic inflammation based on circadian rhythms in order to alleviate clinical signs/symptoms of allergy constantly in line with the circadian rhythms of the body. By using a mouse model for human atopic dermatitis and dogs, time-of-day dependent variations of allergic inflammation were detected, and were shown to be controlled by glucocorticoid derived from the adrenal glands. These results suggested that administration of glucocorticoid drugs based on circadian rhythms might efficiently regulate allergic reactions.

虽然近年来过敏性疾病急剧增加，但尚未建立有效的治疗方法。本研究的目的是阐明基于昼夜节律调节过敏性炎症的机制，以根据身体的昼夜节律持续缓解过敏的临床体征/症状。通过使用人类特应性皮炎的小鼠模型和狗，检测到过敏性炎症的时间依赖性变化，并且显示出受来自肾上腺的糖皮质激素的控制。这些结果表明，基于昼夜节律的糖皮质激素药物给药可能有效地调节过敏反应。

项目成果

Circadian regulation of scratching behavior in NC/Tnd mice, a mouse model for human atopic dermatitis

NC/Tnd 小鼠（人类特应性皮炎小鼠模型）抓挠行为的昼夜节律调节

• 发表时间: 2011
• 作者: Ohmori K;Tanaka A;Matsuda A;Matsuda H
• 通讯作者: Matsuda H

CCAAT/enhancer-bindine protein alpha /EBPalpha)is critical for interleukin-4 expression in response to FcepsilonRI receptor cross-linking

CCAAT/增强子结合蛋白 α /EBPα) 对于响应 FcepsilonRI 受体交联的白细胞介素 4 表达至关重要

• 发表时间: 2011
• 期刊: J.Biol.Chem.
• 作者: Qi X;Nishida J;Chaves L;Ohmori K;Huang H.
• 通讯作者: Huang H.

CCAAT/enhancer-binding protein alpha (C/EBPalpha) is critical for interleukin-4 expression in response to FcepsilonRI receptor cross-linking.

CCAAT/增强子结合蛋白 α (C/EBPα) 对于响应 FcepsilonRI 受体交联的白细胞介素 4 表达至关重要。

• DOI: 10.1074/jbc.m110.213389
• 发表时间: 2011
• 期刊: The Journal of biological chemistry
• 作者: Qi,Xiaopeng;Nishida,Jun;Chaves,Lee;Ohmori,Keitaro;Huang,Hua
• 通讯作者: Huang,Hua

海藻の一種であるカジメに含まれるdieckolの肥満細胞に対する効果

海藻 Kajime 中所含的二烯酚对肥大细胞的影响

• 发表时间: 2012
• 作者: アン・キンネ;田中あかね;他
• 通讯作者: 他

Peroxisome proliferator-activated receptor gamma-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NCA/Tnd mice

过氧化物酶体增殖物激活受体γ介导的树突状细胞功能抑制可预防NCA/Tnd小鼠特应性皮炎的发作

• 发表时间: 2011
• 期刊: J.Allergy Clin.Immunol.
• 作者: Jung K;Tanaka A;Fujita H;Matsuda A;Oida K;Karasawa K;Okamoto N;Ohmori K;Jee Y;Shin T;Matsuda H
• 通讯作者: Matsuda H