Study on the anti-allergic DNA vaccines with nanoparticle in gut mucosal immune system

在本研究中，我们基于食物过敏原分子（鸡蛋、Sova和牛奶）的遗传信息构建了DNA疫苗。我们证明了DNA疫苗对牛奶过敏模型小鼠具有抗过敏激活作用。此外，我们发现DNA疫苗可诱导小鼠脾细胞的抗炎作用。利用这一特性也可能有助于设计和生产新的生理功能疫苗。

In this study, we constructed the DNA vaccine based on the genetic information of the food allergen molecules (egg, Sova, and milk). We demonstrated that the DNA vaccine induced anti-allergic activation on the milk allergic model mice. In addition, we found that DNA vaccine induced the anti-inflammatory effects in the mice splenocytes. Exploiting this property may also prove useful in the design and production of new physiologically functional vaccine.