Development of functional foods and feeds using probiotic lactic acid bacteria DNA

我们发现了来自乳酸菌的寡脱氧核苷酸的强烈的免疫刺激作用，命名为MsST。我们发现，在小鼠免疫细胞中用MsST刺激24小时强烈诱导白细胞介素（IL）-33（IL-1超家族中的细胞因子）的表达。我们合成了一种可生物降解的寡聚脱氧核苷酸胶囊，该胶囊在酸性条件下具有较好的降解性和持续水解性。因此，我们可以将我们的研究扩展到口服给药吸入方法在肠道炎症研究中。

We found the strong immunostimulatory effects of an oligodeoxynucleotide from lactic acid bacteria, designated MsST. We show that 24-hour of stimulation with MsST in mouse immune cells strongly induces expression of interleukin(IL)-33, a cytokine in the IL-1 superfamily. We synthesized biodegradable capsule containing oligodeoxynucleotide, which showed sustaining-hydrolyzed and preferably degraded in acidic condition. Thereby, we could extend our studies in the oral administrative inhaled approach in intestinal inflammation study.