Development of functional foods and feeds using probiotic lactic acid bacteria DNA

我们发现来自乳酸菌的寡脱氧核苷酸具有很强的免疫刺激作用，称为MsST。我们发现，24小时的MsST刺激小鼠免疫细胞强烈诱导白细胞介素(IL)-33的表达，IL -33是IL-1超家族中的一种细胞因子。我们合成了含有寡脱氧核苷酸的可生物降解胶囊，该胶囊在酸性条件下具有持续水解和较好降解的特点。因此，我们可以扩大口服给药吸入方法在肠道炎症研究中的应用。

We found the strong immunostimulatory effects of an oligodeoxynucleotide from lactic acid bacteria, designated MsST. We show that 24-hour of stimulation with MsST in mouse immune cells strongly induces expression of interleukin(IL)-33, a cytokine in the IL-1 superfamily. We synthesized biodegradable capsule containing oligodeoxynucleotide, which showed sustaining-hydrolyzed and preferably degraded in acidic condition. Thereby, we could extend our studies in the oral administrative inhaled approach in intestinal inflammation study.