Search for lipid accumulation inhibitory and lipid metabolismpromoting constituents from medicinal foods

从药用食品中寻找抑制脂质堆积和促进脂质代谢的成分

• 批准号: 20790022
• 负责人: MORIKAWA Toshio
• 金额: $ 2.66万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790022/
• 关键词: 薬用食品; 脂肪蓄積抑制作用; 脂肪代謝促進作用; メタボリックシンドローム; デイジーフラワー; Sapindus rarak; 垂盆草; Piper chaba; ムクロジ; エバーラスティングフラワー; 脂肪蓄積抑制; タイ産ムクロジ; ザクロ花

In order to investigate bioactive constituents from medicinal foods, we examined following extensive screening trials : (1) inhibitory effects on serum triglyceride (TG) elevation in olive oil-treated mice (2) TG accumulation inhibitory activity in HepG2 cells and TG metabolism-promoting activity in high glucose pretreated HepG2 cells, and (3) inhibitory effects on TNF-α-induced cytotoxicity in mouse primary cultured hepatocytes and/or L929 cells. As the results, (1) antihyperlipidemic saponin constituents were obtained from flowers of Bellis perennis and pericarps of Sapindus rarak, (2) lipid accumulation inhibitors were obtained from Sedum sarmentosum, and (3) TNF-α sensitivity degradation principles were obtained from Boesenbergia rotunda, Punica granatum, Helichrysum arenarium, and Piper chaba.

为了研究药用食品中的生物活性成分，我们进行了以下广泛的筛选试验：（1）对橄榄油处理的小鼠中血清甘油三酯（TG）升高的抑制作用（2）HepG 2细胞中TG积累抑制活性和高糖预处理的HepG 2细胞中TG代谢促进活性，（3）抑制TNF-α诱导的小鼠原代肝细胞和/或L929细胞的细胞毒性。结果表明：从多年生花和无患子果皮中分离得到抗高血压的皂苷类成分;从垂盆草中分离得到脂质积累抑制剂;从圆叶牛油果、石榴、沙生蜡菊和胡椒中分离得到TNF-α敏感性降解成分。

项目成果

A new amide, piperchabamide F, and two new phenylpropanoid glycosides, @piperchabaosides A and B, from the fruit of Piper chaba

一种新的酰胺 Piperchabamide F 和两种新的苯丙酸苷 @piperchabaosides A 和 B，来自 Piper chaba 的果实

• 发表时间: 2009
• 期刊: Chemical & Pharmaceutical Bulletin 57
• 作者: Morikawa T.;et al.
• 通讯作者: et al.

タイ天然薬物ムクロジ(Sapindus rarak)果皮の血中中性脂質上昇抑制作用成分

泰国天然药物无患子（Sapindus rarak）果皮抑制血液中性脂质上升

• 发表时间: 2008
• 作者: 森川敏生;謝媛媛;岡本将揮;二宮清文;村岡修;松田久司;浅尾恭伸;濱尾 誠;吉川雅之;袁丹;Pongpiriyadacha Yutana
• 通讯作者: Pongpiriyadacha Yutana

垂盆草(Sedum sarmentosum)の肝保護および抗TNF-α作用成分

垂盆草的保肝及抗TNF-α活性成分

• 发表时间: 2008
• 作者: 二宮清文;森川敏生;村岡修;張偉;中村誠宏;松田久司;吉川雅之
• 通讯作者: 吉川雅之

Medicinal foodstuffs.: XXXIV.: Structures of new prenylchalcones and prenylflavanones with TNF-α and aminopeptidase N inhibitory activities from Boesenbergia rotunda

• DOI: 10.1248/cpb.56.956
• 发表时间: 2008-07-01
• 期刊: CHEMICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 1.7
• 作者: Morikawa, Toshio;Funakoshi, Kanako;Yoshikawa, Masayuki
• 通讯作者: Yoshikawa, Masayuki

Medicinal flowers. XXVII. New flavanone and chalcone glycosides, arenariumosides I, II, III, and IV, and tumor necrosis factor-α inhibitors from Everlasting, flowers of Helichrysum arenarium

药用花卉。来自永生花的新黄烷酮和查耳酮苷、沙星苷 I、II、III 和 IV，以及肿瘤坏死因子-α 抑制剂。

• 发表时间: 2009
• 期刊: Chemical & Pharmaceutical Bulletin 57
• 作者: Morikawa T.;et al.
• 通讯作者: et al.