Study for molecular and neural mechanisms underlying abused druginduced neuropsychosis using organotypic slice cultures

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We found that repeated exposure to various types of abused drugs, such as methamphetamine, cocaine and morphine, commonly induced the augmentation of dopamine release (dopaminergic sensitization) in the rat mesocorticolimbic dopaminergic slice co-cultures. Furthermore, in rat raphe serotonergic slice culture, sustained exposure to MDMA induced marked augmentation of exocytotic serotonin release, which is different from acute MDMA-evoked serotonin efflux.