A novel method for analyzing inner ear disorders using disease-specific iPS cells
A novel method for analyzing inner ear disorders using disease-specific iPS cells
批准号:
22591878
负责人:
NAKAGAWA Takayuki
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
To utilize disease-specific iPS cells for the development of novel therapeutics for inner ear diseases, methods for otic induction of iPS cell have been developed, which have high efficiency for induction of hair cell-like cells. We also generated iPS cell lines derived from TRIOBP deficiency mice, and examined their potential for hair cell differentiation. For further progress, a method for induction of mature hair bundles should be established.
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