Roles of TRP channels expressed in immune and glial cells in chronic pain

慢性疼痛，如外周神经损伤引起的神经性疼痛，是基于外周和中枢致敏，这是由外周/脊髓神经元和免疫/胶质细胞相互作用介导的神经炎症引起的。在本研究中，我们发现免疫/胶质细胞中表达的瞬时受体电位（TRP）通道在慢性疼痛中起重要作用。特别是，我们研究了TRPM2在小鼠炎症性和神经性疼痛中的作用，TRPM2在巨噬细胞和小胶质细胞中作为活性氧（ROS）的传感器

Chronic pain, such as peripheral nerve injury-induced neuropathic pain, is based on both peripheral and central sensitization, which is caused by neuroinflammation mediated by the interaction between peripheral/spinal neurons and immune/glial cells. In this research, we found that transient receptor potential (TRP) channels expressed in immune/glial cells play an important role in chronic pain. Especially, we examined the roles of TRPM2, which acts as a sensor for reactive oxygen species (ROS) in macrophages and microglia, in inflammatory and neuropathic pain in mice