Characterization of the PA5471 gene involved in the antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa.
Characterization of the PA5471 gene involved in the antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa.
批准号:
20790079
负责人:
MORITA Yuji
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
The multidrug efflux system MexXY which is one of major antimicrobial resistant determinants in Pseudomonas aeruginosa is induced via the PA5471 gene product which is inducible by ribosome-targeting antimicrobial agents. A 13-amino-acid open reading frame (PA5471.1) is c.a. 250 bp upstream of the PA5471 coding sequence and its translational repression leads transcriptional inducibility of the PA5471 (or MexXY). The transcriptional termination of the PA5471.1 was implied to be the Rho-factor dependent.
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会议论文
DOI:
10.1016/j.mimet.2010.06.001
发表时间:
2010-09-01
期刊:
JOURNAL OF MICROBIOLOGICAL METHODS
影响因子:
2.2
作者:
[Morita, Yuji, Narita, Shin-Ichiro, Kawamura, Yoshiaki]
通讯作者:
Kawamura, Yoshiaki
緑膿菌必須遺伝子条件的破壊株構築法の開発
铜绿假单胞菌必需基因条件破坏菌株构建方法的开发
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[森田雄二, ら]
通讯作者:
ら
Metagenomic approach to identify agents to restore anti-pseudomonas drugs against multidrug resistant Pseudomonas aeruginosa (MDRP): use of MDRP mutants lacking multidrug efflux pumps.
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批准号:23790106
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:MORITA Yuji
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依托单位:
海外基金