Strategy for inhibition of HIV-1 replication without appearance of drug resistant virus and attenuation of the virus

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N-Myristoyltransferase (NMT) isozymes, NMT1 and NMT2, are essential host factors for human immunodeficiency virus type-1 (HIV-1), by which the viral proteins Pr55^(gag) and Nef are N-myristoylated. The study demonstrated that the N-terminal region of each NMT isozyme was required for the isozyme-specific binding to ribosome. The each isozyme specific binding to ribosome was associated with HIV-1 release, in which NMT1 and NMT2 in ribosome were respectively related to Pr55^(gag) and Nef. These results implicate that the N-terminal region mediated binding to ribosome could become target for NMT isozyme-specific inhibition, which could block HIV-1 release.