A study on the mechanism for the dynamic position control of neuronal inward rectifier potassium channels.

我们开发了一种使用几种荧光蛋白的成像方法，我成功地观察了活细胞中Kir通道的细胞内动力学。我提供的证据表明，Kir亚型组成的通道戏剧性地决定细胞内动力学。这一机制可能是基尔通道位置控制的基础。在本研究中，我们还检测了临床上用于治疗神经疾病的药物对Kir通道功能的直接影响，我们发现一些药物，如一系列抗抑郁药或抗精神病药，通过与神经胶质Kir通道（Kir4.1通道）孔的中央腔结合来抑制其功能。

We have developed a imaging method with several fluorescent proteins, I successfully observed the intracellular dynamics of Kir channels in living cells. I provided the evidences that Kir subtypes that compose the channel dramatically determine the intracellular dynamics. This mechanism may underlie the position control of Kir channels. In this study, we also examined the direct effect of drugs that clinically used in the treatments for neural disorders on Kir channel function, we found that several drugs, such as a series of antidepressants or antipsychotics, inhibit glial Kir channel (Kir4.1 channel) function by binding with the central cavity of it's pore.