Molecular mechanisms for cell migration
Molecular mechanisms for cell migration
批准号:
20790225
负责人:
WATANABE Takashi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
定向细胞迁移是一种精心安排的细胞过程,是胚胎发生、创伤愈合、血管生成以及肿瘤发生等多种生理过程所必需的。迁移细胞具有明显的极性,形成前后轴方向。本研究以Rho家族的GTP酶为研究对象,探讨其在细胞极性迁移中的作用机制。
英文摘要
Directional cell migration is orchestrated cellular process that is required for a variety of physiological processes such as embryogenesis, wound healing, angiogenesis, as well as carcinogenesis. Migrating cells show a distinct polarity with forming front-rear axis toward the direction. In this study, focusing on Rho family GTPases that is critical regulator in polarized migration, we aimed to elucidate the molecular mechanisms governing migratory behavior and cell polarity.
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Mutational analysis of SOS1 in acute myeloid leukemia
急性髓系白血病SOS1突变分析
DOI:
--
发表时间:
2008
期刊:
Int J Hematol 88(4)
影响因子:
--
作者:
[Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T]
通讯作者:
Naoe T
DOI:
10.1002/cm.20444
发表时间:
2010-05-01
期刊:
CYTOSKELETON
影响因子:
2.9
作者:
[Itoh, Norimichi, Nakayama, Masanori, Kaibuchi, Kozo]
通讯作者:
Kaibuchi, Kozo
DOI:
10.1101/cshperspect.a003020
发表时间:
2009-09
期刊:
Cold Spring Harbor perspectives in biology
影响因子:
7.2
作者:
[Takashi Watanabe;Kazuhide Sato;K. Kaibuchi]
通讯作者:
Takashi Watanabe;Kazuhide Sato;K. Kaibuchi
Targeting of Tiam1 to focal adhesion through Talin for Rac1 activation and cell migration.
通过 Talin 将 Tiam1 靶向粘附斑,以实现 Rac1 激活和细胞迁移。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Watanabe, T., Wang, S., Matsuzawa, K., Sato, K., Kakeno, M., Kaibuchi K.]
通讯作者:
Kaibuchi K.
Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases.(Cold Spring Harb Perspect Biol, 1)
钙粘蛋白介导的细胞间粘附和涉及小 GTP 酶的信号级联。(Cold Spring Harb Perspect Biol,1)
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Watanabe, T., Sato, K., Kaibuchi, K.]
通讯作者:
K.
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