Detection of CHOP gene rearrangements in myxoid liposarcoma by PCR and FISH analyses

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Myxoid liposarcoma has the specific fusion gene such as TLS/FUS-CHOP. We tried to detect TLS/FUS-CHOP fusion gene transcript by RT-PCR or CHOP gene rearrangement by FISH using formalin-fixed paraffin-embedded specimens. Contrasting the two analyses, FISH was more sensitive than RT-PCR. The histologically different components involving myxomatous, white adipose, brown adipose and round cell ones in the same tumor had the identical CHOP gene rearrangement. It suggests that the phenotypic expression of the inside of myxoid liposarcoma are not directly influenced by TLS/CHOP fusion gene.