Regulation of autoimmunity by B lymphocyte coreceptor CD72

B 淋巴细胞辅助受体 CD72 对自身免疫的调节

• 批准号: 20790371
• 负责人: WATANABE Kozo
• 金额: $ 2.75万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790371/
• 关键词: 免疫寛容; 自己免疫; 免疫寛容・自己免疫; CD72; Cタイプ様レクチン; Bリンパ球; 糖鎖リガンド

In this study, I suggested that CD72 interacts with glycan by glycan array analysis and surface plasmon resonance analysis using purified recombinant CD72 protein. I also suggested that CD72 negatively regulates B cell proliferation by B cell antigen receptor ligation in the presence of CD72 glycan ligand by the experiments using purified B cells from CD72 defficient mice. These results suggest a new mechanism of negative regulation of a B cell immune response by the CD72 glycan ligand-CD72

在本研究中，我建议通过聚糖阵列分析和纯化重组CD72蛋白的表面等离子体共振分析，CD72与聚糖相互作用。我还通过使用CD72缺陷小鼠纯化的B细胞进行实验，提出在CD72聚糖配体存在的情况下，CD72通过B细胞抗原受体连接负调节B细胞增殖。这些结果提示了CD72聚糖配体-CD72负调控B细胞免疫应答的新机制

项目成果

The C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 carries a Ca2+-independent lectin activity to oligomannose

含有C型凝集素样结构域的B淋巴细胞膜分子CD72对寡甘露糖具有Ca2独立的凝集素活性

• 发表时间: 2008
• 作者: Watanabe Kozo;Adachi Takahiro and Tsubata Takeshi
• 通讯作者: Adachi Takahiro and Tsubata Takeshi

Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation.

• DOI: 10.1016/j.bbrc.2008.07.013
• 发表时间: 2008-09
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Kozo Watanabe;S. Ichinose;Koji Hayashizaki;T. Tsubata

Synthesis of biotinylated sialoside to probe CD22-ligand interactions

• DOI: 10.1016/j.tetlet.2009.05.044
• 发表时间: 2009-08-05
• 期刊: TETRAHEDRON LETTERS
• 影响因子: 1.8
• 作者: Abdu-Allah, Hajjaj H. M.;Watanabe, Kozo;Kiso, Makoto
• 通讯作者: Kiso, Makoto

Potent small molecule mouse CD22-inhibitors: Exploring the interaction of the residue at C-2 of sialic acid scaffold

• DOI: 10.1016/j.bmcl.2009.08.044
• 发表时间: 2009-10-01
• 期刊: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
• 影响因子: 2.7
• 作者: Abdu-Allah, Hajjaj H. M.;Watanabe, Kozo;Kiso, Makoto
• 通讯作者: Kiso, Makoto

Potent Small Molecule Mouse CD22 Inhibitors: Exploring the Interaction of the Residue at C-2 of Sialic Acid Scaffold Bioorg.

有效的小分子小鼠 CD22 抑制剂：探索唾液酸支架 Bioorg C-2 残基的相互作用。

• 发表时间: 2009
• 期刊: Med.Chem.Lett. 19
• 作者: Abdu-Allah;H.H.M.;Watanabe;K.;Hayashizaki;K.;Takaku;C.;Tamanaka;T.;Takematsu;H.;Kozutsumi;Y.;Tsubata;T.;Ishida;H.;Kiso;M.
• 通讯作者: M.