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Regulation of autoimmunity by B lymphocyte coreceptor CD72

Regulation of autoimmunity by B lymphocyte coreceptor CD72
B 淋巴细胞辅助受体 CD72 对自身免疫的调节
批准号:
20790371
负责人:
WATANABE Kozo
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
In this study, I suggested that CD72 interacts with glycan by glycan array analysis and surface plasmon resonance analysis using purified recombinant CD72 protein. I also suggested that CD72 negatively regulates B cell proliferation by B cell antigen receptor ligation in the presence of CD72 glycan ligand by the experiments using purified B cells from CD72 defficient mice. These results suggest a new mechanism of negative regulation of a B cell immune response by the CD72 glycan ligand-CD72
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The C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 carries a Ca2+-independent lectin activity to oligomannose
含有C型凝集素样结构域的B淋巴细胞膜分子CD72对寡甘露糖具有Ca2独立的凝集素活性
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Watanabe Kozo, Adachi Takahiro and Tsubata Takeshi]
通讯作者: Adachi Takahiro and Tsubata Takeshi
DOI: 10.1016/j.bbrc.2008.07.013
发表时间: 2008-09
期刊: Biochemical and biophysical research communications
影响因子: 3.1
作者: [Kozo Watanabe;S. Ichinose;Koji Hayashizaki;T. Tsubata]
通讯作者: Kozo Watanabe;S. Ichinose;Koji Hayashizaki;T. Tsubata
DOI: 10.1016/j.tetlet.2009.05.044
发表时间: 2009-08-05
期刊: TETRAHEDRON LETTERS
影响因子: 1.8
作者: [Abdu-Allah, Hajjaj H. M., Watanabe, Kozo, Kiso, Makoto]
通讯作者: Kiso, Makoto
DOI: 10.1016/j.bmcl.2009.08.044
发表时间: 2009-10-01
期刊: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
影响因子: 2.7
作者: [Abdu-Allah, Hajjaj H. M., Watanabe, Kozo, Kiso, Makoto]
通讯作者: Kiso, Makoto
16
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
      $28.62万
    • 财政年份:
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    • 财政年份:
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