Regulation of autoimmunity by B lymphocyte coreceptor CD72
Regulation of autoimmunity by B lymphocyte coreceptor CD72
批准号:
20790371
负责人:
WATANABE Kozo
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
In this study, I suggested that CD72 interacts with glycan by glycan array analysis and surface plasmon resonance analysis using purified recombinant CD72 protein. I also suggested that CD72 negatively regulates B cell proliferation by B cell antigen receptor ligation in the presence of CD72 glycan ligand by the experiments using purified B cells from CD72 defficient mice. These results suggest a new mechanism of negative regulation of a B cell immune response by the CD72 glycan ligand-CD72
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The C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 carries a Ca2+-independent lectin activity to oligomannose
含有C型凝集素样结构域的B淋巴细胞膜分子CD72对寡甘露糖具有Ca2独立的凝集素活性
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Watanabe Kozo, Adachi Takahiro and Tsubata Takeshi]
通讯作者:
Adachi Takahiro and Tsubata Takeshi
DOI:
10.1016/j.bbrc.2008.07.013
发表时间:
2008-09
期刊:
Biochemical and biophysical research communications
影响因子:
3.1
作者:
[Kozo Watanabe;S. Ichinose;Koji Hayashizaki;T. Tsubata]
通讯作者:
Kozo Watanabe;S. Ichinose;Koji Hayashizaki;T. Tsubata
DOI:
10.1016/j.tetlet.2009.05.044
发表时间:
2009-08-05
期刊:
TETRAHEDRON LETTERS
影响因子:
1.8
作者:
[Abdu-Allah, Hajjaj H. M., Watanabe, Kozo, Kiso, Makoto]
通讯作者:
Kiso, Makoto
DOI:
10.1016/j.bmcl.2009.08.044
发表时间:
2009-10-01
期刊:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
影响因子:
2.7
作者:
[Abdu-Allah, Hajjaj H. M., Watanabe, Kozo, Kiso, Makoto]
通讯作者:
Kiso, Makoto
Potent Small Molecule Mouse CD22 Inhibitors: Exploring the Interaction of the Residue at C-2 of Sialic Acid Scaffold Bioorg.
有效的小分子小鼠 CD22 抑制剂:探索唾液酸支架 Bioorg C-2 残基的相互作用。
DOI:
--
发表时间:
2009
期刊:
Med.Chem.Lett. 19
影响因子:
--
作者:
[Abdu-Allah, H.H.M., Watanabe, K., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.]
通讯作者:
M.
共 16 条
Building a Study of Pan-Pacific Civilization from an anthropological perspective based on Environmental Archaeology
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批准号:25244046
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$28.62万
-
财政年份:2013
-
负责人:WATANABE Kozo
-
依托单位:
Suppression of autoimmunity by B lymphocyte membrane protein CD72
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批准号:23790531
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
-
财政年份:2011
-
负责人:WATANABE Kozo
-
依托单位:
Actuality of anthropological thought of Marcel Mauss
-
批准号:22520835
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.91万
-
财政年份:2010
-
负责人:WATANABE Kozo
-
依托单位:
Conflict between indigenous and exogenous legal systems concerning the life-world, i.e. the land as its natural and cultural base
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批准号:14310150
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.48万
-
财政年份:2002
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负责人:WATANABE Kozo
-
依托单位:
海外基金