Effect of cognitive function mediated by NMDA receptor activation of new nootropic drug.

在这项研究中，我们证明了奈非西坦通过激活CaM激酶II来调节认知功能(Moriuchi等人，J.Neurochem)。奈非拉西坦通过激活CaM激酶II和PKC增加嗅球切除小鼠认知功能的损害(Moriuchi等人，J.Neurochem)。奈非拉西坦通过突触前烟碱乙酰胆碱受体增强大鼠皮质神经元上的谷氨酸能系统(MOriguchi等人，Neurosciness，2009)，而加兰他明通过激活CaM Kinase II调节认知功能(MOriguchi等人，海马体，2009)。

In this present study, we demonstrated that nefiracetam mediates cognitive function through activation of CaM kinase II (Moriguchi et al., J. Neurochem. 2008), and nefiracetam augments the impairment of coginitive function through activation of CaM kinase II and PKC in olfactory bulbectomized mice (Moriguchi et al., J. Neurochem. 2009), and nefiracetam enhances glutamatergic system via presynaptic nicotinic acethylcholine receptors in rat cortical neurons (Moriguchi et al., Neuroscinece 2009), and galantamine mediates cognitive function through activation of CaM kinase II (Moriguchi et al., Hippocampus, 2009).