A basic research in relation to stress and hypotension

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The SART (specific alternation of rhythm in temperature)-stressed rat, which is a model animal of autonomic imbalance, is associated with low blood pressure and tachycardia under both consciousness and anesthesia. Additionally, orthostatic hypotension (OH) is developed easily by postural manipulation of SART-stressed rats. Accordingly, we studied the influence of the adrenalin α1 receptor agonist phenylephrine on stress-induced OH. In SART-stressed rats, prolonged intravenous administration of phenylephrine reduced OH. Sympathetic dysfunction is suggested to be a factor underlying SART stress-induced OH.