Analysis of the mechanism of fulminant hepatitis using a hepatitisB virus strain obtained from a patient in fulminant hepatitis outbreak

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To clarify the mechanism of fulminant hepatitis induced by hepatitis B virus (HBV), we focused on a HBV strain obtained from a patient in fulminant hepatitis outbreak, and investigated the significance of mutations found in the strain and the impact to the infected cells. As a result, we demonstrated that the HBV replicative intermediates of HBV with the mutations were increase in the cells, and HBV core protein was accumulated in the nucleus of HBV-transfected cells. Moreover, the strain had direct cytotoxicity, and a part mechanism of fulminant hepatitis was clarified.