课题基金 / 基金详情

Development of new anti-fibrotic therapy based on the regulation of hepatic stellate cell by liver specific dendritic cell.

Development of new anti-fibrotic therapy based on the regulation of hepatic stellate cell by liver specific dendritic cell.
开发基于肝脏特异性树突状细胞对肝星状细胞的调节的新型抗纤维化疗法。
批准号：
20790514
负责人：
SATO Kenichi
金额：
$2.66万
依托单位：
Jikei University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790514/
关键词：
肝線維化星細胞制御性樹状細胞樹状細胞HSCNKNKTTGFβ

项目摘要

项目成果

SATO Kenichi的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
To establish the new anti--fibrotic therapy based on the regulation of hepatic stellate cell (HSC) by liver specific dendritic cell, I analyzed the effect of CD4, NK, NKT, Treg and CD8 cell on the activation of HSC. Both CD4 cell and NK cell activated HSC, however, NKT, Treg and CD8 cell did not influence on the activation of HSC. Induced regulatory DC did not induce the apoptosis of HSC. DCreg did not influence on the interaction between HSC and CD4, NK, NKT, Treg and CD8 cell. The administration of liver specific DCreg to the mouse model of liver fibrosis did not showed significant anti-inflammatory effect.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Accumulation of functional regulatory T cells in actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation
DOI： 10.1016/j.clim.2009.12.002
发表时间： 2010-04-01
期刊： CLINICAL IMMUNOLOGY
影响因子： 8.6
作者： [Saeki, Chisato, Nakano, Masanori, Zeniya, Mikio]
通讯作者： Zeniya, Mikio
Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice
DOI： 10.1002/jmv.21859
发表时间： 2010-09
期刊： Journal of Medical Virology
影响因子： 12.7
作者： [Kenichi Satoh;Hiroki Takahashi;C. Matsuda;Toshiyuki Tanaka;M. Miyasaka;M. Zeniya;M. Kohara]
通讯作者： Kenichi Satoh;Hiroki Takahashi;C. Matsuda;Toshiyuki Tanaka;M. Miyasaka;M. Zeniya;M. Kohara
Insulin resistance was involved in the pathogenesis of autoimmune hepatitis without the relation to prednisone therapy
胰岛素抵抗参与自身免疫性肝炎的发病机制，与泼尼松治疗无关
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Takahashi H, et al.]
通讯作者： et al.
Serum ALT in normal level of healthy individuals positively and independently correlates to the markers of metabolic syndrome.
健康个体正常水平的血清 ALT 与代谢综合征的标志物呈正相关且独立相关。
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Takahashi H, et al.]
通讯作者： et al.
共 6 条
    Recognition of Dutch in Early American Literature: Puritans as an Origin of Diversity
    • 批准号：
      15K02353
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.33万
    • 财政年份：
      2015
    • 负责人：
      SATO Kenichi
    • 依托单位：
      Tokyo University of Science
    New method for aiding detection of abnormal thyroid function in patients making use of set of routine tests – applying it in screening during general health check-ups or visiting hospitals
    Development of the spectral analytical algorithm for determination of noninvasive blood glucose using t mid-infrared spectroscopy
    Images of Foreigners in 18th Century German and British Popular Dramas
    • 批准号：
      24520335
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.16万
    • 财政年份：
      2012
    • 负责人：
      SATO Kenichi
    • 依托单位：
      Tohoku University
    海外基金