Development of the new method to assist diagnosing thyroid dysfunction adopting a combination of routine test data that was already measured during health-checkup, and its clinical application

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We developed a new simple, low-cost method for detecting patients with overt thyroid dysfunction (PTD) using the combination of six routine tests already measured without measuring thyroid hormone. The existing procedure comprised 6 routine tests (alkaline phosphatase (ALP), serum creatinine (S-Cr), total cholesterol (TC), heart rate (HR), lactate dehydrogenase (LDH) and red blood cell (RBC)). Correcting for the effect of dosing in examinees taking cholesterol-lowering agents and extending to treat time series variation in routine tests succeeded in decreasing both false negatives and false positives. We performed this screening for many participants attending health-checkup at Ningen Docks in JR Sendai Hospital and Tohoku Kousai Hospital, and found more than 30 PTDs, none of them was suspected of thyroid dysfunction by a medical examination. More than 10,000 PTDs will be discovered annually if such screening is performed at all Ningen Docks in Japan.