The investigation into the endocytosis-mediated effects of the steroid hormones in renal proximal tubular epithelial cells

我对肾近端小管上皮细胞（PTEC）内吞类固醇激素醛固酮等作用的可能性进行了基本检查，并检查了肾素-血管紧张素系统（RAS）与醛固酮在PTEC中密切相关的内吞受体meggalin的表达控制。首先，在PTEC中确认醛固酮受体MR和醛固酮反应基因SGK1的蛋白水平。其次，阐明了与胰岛素受体的串扰，恢复了血管紧张素II对PTEC中Megalin表达抑制的控制。

I performed basic examination of possibility to have action through endocytosis of steroid hormone aldosterone etc in renal proximal tubular epithelial cells (PTEC), and I examined the expressional control of endocytotic receptor megalin by renin-angiotensin system (RAS) with a closely relation of aldosterone in PTEC. First, protein level of aldosterone receptor MR and aldosterone response gene SGK1 was confirmed in PTEC. Second, it was clarified the crosstalk with the insulin sinal that recovered the control of angiotensin II on the suppression of Megalin expression in PTEC.