The novel mechanism of the phosphate transporter Npt2a dependent regulation of vitamin D homeostasis in kidney
The novel mechanism of the phosphate transporter Npt2a dependent regulation of vitamin D homeostasis in kidney
批准号:
20790594
负责人:
YAMAMOTO Hironori
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
点击翻译按钮获取中文摘要
英文摘要
In this study, we analyzed the molecular mechanism of new regulation of vitamin D metabolism by thyroid hormone 13 in kidney. We demonstrated that thyroid hormone receptor betal and VDIR is important factor for the T3-dependent repression of the vitamin D synthesis enzyme Cyp27b1 gene. And, we found that the neither VDR nor Klotho was essential to the Cyp27bl gene control by T3, furthermore, we demonstrated that the phosphate transporter Npt2a gene play a critical role for the T3-dependent renal Cyp27bl gene repression using the Npt2a deficient mice.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1016/j.bbrc.2008.02.004
发表时间:
2008-04-11
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Harada, Nagakatsu, Yonemoto, Haruka, Nakaya, Yutaka]
通讯作者:
Nakaya, Yutaka
Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoc last differentiation is associated with switching between NADPH oxidase homologues.
核因子-κB 配体诱导的小鼠破骨细胞分化的受体激活剂与 NADPH 氧化酶同源物之间的转换有关。
DOI:
--
发表时间:
2009
期刊:
Free Radic Biol Med. 47(2)
影响因子:
--
作者:
[Tsuji M, Yamamoto H, Sato T, Mizuha Y, Kawai Y, Taketani Y, Kato S, Terao J, Inakuma T, Takeda E, Shuto E, Uebanso T, Sasaki H]
通讯作者:
Sasaki H
食餌性リン制限および活性型ビタミンD3によるFibrobrast growth factor 15遺伝子の発現調節
通过膳食磷限制和活性维生素 D3 调节成纤维细胞生长因子 15 基因表达
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[中橋乙起, 山本浩範, 田中更沙, 菊地浩子, 金子一郎, 竹谷豊, 宮本賢一, 加藤茂明, 武田英二]
通讯作者:
武田英二
Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice
小鼠中甘油-3-磷酸酰基转移酶 1 基因表达所需的顺式作用启动子序列的鉴定
DOI:
--
发表时间:
2009
期刊:
Biochim Biophys Acta 1791
影响因子:
--
作者:
[Nakagasva T, Yin Y, Hattori A, Zenitani T, Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, Hosaka T, Takahashi A, Yoshimoto K. Nakaya Y]
通讯作者:
Yoshimoto K. Nakaya Y
DOI:
10.1677/jme-08-0161
发表时间:
2009-03-01
期刊:
JOURNAL OF MOLECULAR ENDOCRINOLOGY
影响因子:
3.5
作者:
[Takei, Yuichiro, Yamamoto, Hironori, Takeda, Eiji]
通讯作者:
Takeda, Eiji
共 40 条
Disease-specific intestinal nutrient sensing mechanismand the development of special nutrition foods
-
批准号:23650482
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:YAMAMOTO Hironori
-
依托单位:
A Research Project for Diagnosis, Treatment and Pathophysiology of Small Intestinal Diseases Using Double-Balloon Endoscopy.
-
批准号:16590623
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2004
-
负责人:YAMAMOTO Hironori
-
依托单位: