A basic study for Application to treatment of the refractory glomerulonephritis using CD26

CD26在T细胞活化中起重要作用，是共刺激分子。我们证明，在CD3和CD26的共同刺激下，外周血T细胞表面的脂筏表达水平随着时间的推移而增加。此外，外周血T细胞经抗CD26抗体处理后，脂筏表面表达增加。另一方面，在免疫抑制药物的协同刺激作用下，T细胞上脂筏的表达随药物浓度和时间的延长而降低，T细胞的增殖受到抑制。我们的结果提示，当我们评估免疫抑制药物对肾炎患者的疗效时，脂筏可能成为生物标志物。

CD26 has an important role in T-cell activation and is costimulatory molecule. We demonstrated that the expression level of lipid rafts to the peripheral blood T cell surface increased over time by costimulation of CD3 and CD26. Moreover, anti CD26 antibody treatment of peripheral blood T cells led to increased surface expression of Lipid rafts. On the other hand, after costimulation under the immunosuppressive drugs treatment, the expression of lipid rafts on T cells decreases drugs concentration-dependently and over time with T-cell proliferation being inhibited. Our results suggest that lipid rafts may become the biomarker when we evaluate the effect of the immunosuppressive drug in patients with glomerulonephritis.