A basic study for Application to treatment of the refractory glomerulonephritis using CD26

CD26在T细胞活化中具有重要作用，是一种共刺激分子。我们证明，脂筏表达水平的外周血T细胞表面的CD3和CD26的共刺激随着时间的推移而增加。此外，抗CD26抗体处理外周血T细胞导致脂质筏表面表达增加。另一方面，在免疫抑制药物处理下的共刺激后，T细胞上的脂筏表达随药物浓度依赖性和时间推移而降低，同时T细胞增殖被抑制。我们的研究结果表明，脂筏可能成为生物标志物，当我们评价免疫抑制剂在肾小球肾炎患者的效果。

CD26 has an important role in T-cell activation and is costimulatory molecule. We demonstrated that the expression level of lipid rafts to the peripheral blood T cell surface increased over time by costimulation of CD3 and CD26. Moreover, anti CD26 antibody treatment of peripheral blood T cells led to increased surface expression of Lipid rafts. On the other hand, after costimulation under the immunosuppressive drugs treatment, the expression of lipid rafts on T cells decreases drugs concentration-dependently and over time with T-cell proliferation being inhibited. Our results suggest that lipid rafts may become the biomarker when we evaluate the effect of the immunosuppressive drug in patients with glomerulonephritis.