Analysis of IL-33-induced asthma model

哮喘是一种具有异质性表型的综合征。然而，这种异质性的致病机制在很大程度上仍然未知。IL-33是2005年报道的一种致敏细胞因子，为了研究IL-33在哮喘中的作用，我建立并研究了一种新的哮喘小鼠模型。通过该模型，我观察到了部分重症哮喘的表现，并获得了il -33相关致病性炎症的一些新机制。

Asthma is a syndrome with a heterogeneous phenotype. However, the pathogenic mechanisms of this heterogeneity are still largely unknown. To investigate the asthma-related roles of IL-33, which was reported in 2005 as an allergenic cytokine, I have established and studied a new mouse model of asthma. Using this model, I have been observed a part of the severe asthma manifestation and acquired some novel mechanisms in IL-33-related pathogenic inflammation.