Detection of imprinting abnormalities in rhabdomyosarcoma patients using tumor and serum DNA.
Detection of imprinting abnormalities in rhabdomyosarcoma patients using tumor and serum DNA.
批准号:
20790738
负责人:
KIKUCHI Ken
金额:
$1.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In RMS cell lines and RMS tumor samples, we were able to detect a methylation abnormality in the imprinting center, in other words, imprinting abnormalities in IGF2 and H19 by Melting Curve Analysis. In RMS tumor samples, it was suggested that imprinting abnormalities correlate with the expression of IGF2 mRNA. Furthermore, we established a method to detect imprinting abnormalities in IGF2 and H19 in serum DNA.
期刊论文(0)
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会议论文
Detection of IGF2 and H19 imprinting abnormalities in rhabdomyosarcoma patients using tumor and serum DNA
使用肿瘤和血清 DNA 检测横纹肌肉瘤患者的 IGF2 和 H19 印迹异常
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Ken Kikuchi, Tomoko Iehara, Hajime Hosoi]
通讯作者:
Hajime Hosoi
DOI:
10.1158/1078-0432.ccr-08-2955
发表时间:
2009-06-15
期刊:
CLINICAL CANCER RESEARCH
影响因子:
11.5
作者:
[Miyachi, Mitsuru, Kakazu, Naoki, Hosoi, Hajime]
通讯作者:
Hosoi, Hajime
横紋筋肉腫患者血清遊離DNAを用いたIGF2/H19 imprinting異常の検出
使用横纹肌肉瘤患者血清游离DNA检测IGF2/H19印记异常
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Miyachi M, Kakazu N, Yagyu S, Katsumi Y, Tsubai-Shimizu S, Kikuchi K, Tsuchiya K, Iehara T, Hosoi H., 菊地顕]
通讯作者:
菊地顕
Epitope of causative microorganism of primary biliary cirrhosis
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批准号:21590494
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2009
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负责人:KIKUCHI Ken
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依托单位:
海外基金