Relation between abnormalities of serotonergic neurons and anxiety-related behaviors on prenatally ethanol-exposed rats
Relation between abnormalities of serotonergic neurons and anxiety-related behaviors on prenatally ethanol-exposed rats
批准号:
20790766
负责人:
OHTA Kenichi
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
We investigated the serotonergic system and anxiety-related behavior of rats prenatally exposed to ethanol. Anxiety-related behavior tests revealed that the susceptibility to anxiety was decreased in prenatally ethanol-exposed rats. However, their innate fears were facilitated only when they were exposed to intensive aversive stimuli. The abnormalities of anxiety-related behaviors might be attributed to the depressed serotonergic action as a result of a reduced number of serotonergic cells in the midbrain raphe nuclei or the abnormal fluctuation in brain serotonin during development.
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胎生期エタノール曝露による周性期5-HT動態の変化
产前乙醇暴露导致的周环 5-HT 动力学变化
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[太田健一, 坂田ひろみ, 福井義浩]
通讯作者:
福井義浩
Alteration in anxiety-related behaviorstand reduction of serotonergic neurons in raphe nuclei in adult rats prenatally exposed to ethanol
产前暴露于乙醇的成年大鼠焦虑相关行为的改变和中缝核中血清素能神经元的减少
DOI:
--
发表时间:
2010
期刊:
Congenital Anomalies 50(2)
影响因子:
--
作者:
[Ohta K., Sakata-Haga, H., Fukui Y]
通讯作者:
Fukui Y
Alteration in anxiety-related behaviors and reduction of serotonergic neurons in raphe nuclei in adult rats prenatally exposed to ethanol.
产前接触乙醇的成年大鼠焦虑相关行为的改变和中缝核中血清素能神经元的减少。
DOI:
--
发表时间:
期刊:
Congenital Anomalies (In press)
影响因子:
--
作者:
[Ohta K., Sakata-Haga, H., Fukui Y, Ken-ichi Ohta]
通讯作者:
Ken-ichi Ohta
胎生期アルコール曝露によって障害される受動的回避行動
产前酒精暴露损害被动回避行为
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ohta K., Sakata-Haga, H., Fukui Y, Ken-ichi Ohta, 太田健一]
通讯作者:
太田健一
胎生期エタノール曝露による周生期5-HT動態の変化
产前乙醇暴露导致围产期 5-HT 动态变化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ohta K., Sakata-Haga, H., Fukui Y, Ken-ichi Ohta, 太田健一, 太田健一]
通讯作者:
太田健一
共 6 条
Etiological mechanisms of anxiety disorders induced by fetal alcohol exposure with special reference to fear condition and dynamics state of serotonin.
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批准号:22791029
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:OHTA Kenichi
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依托单位:
Study on state- regulated prostitution in Japanese modern times
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批准号:11610359
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1999
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负责人:OHTA Kenichi
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依托单位:
海外基金