Etiological mechanisms of anxiety disorders induced by fetal alcohol exposure with special reference to fear condition and dynamics state of serotonin.
Etiological mechanisms of anxiety disorders induced by fetal alcohol exposure with special reference to fear condition and dynamics state of serotonin.
胎儿酒精暴露引起焦虑症的病因学机制，特别涉及恐惧状况和血清素动态状态。
批准号：
22791029
负责人：
OHTA Kenichi
金额：
$2.58万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
中文摘要
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英文摘要
Previous study revealed that abnormalities of brain development induced by fetal alcohol exposure(FAE) were recovered by administration of serotonin 1A receptor agonist during period of brain development. In addition, we found disruption of dynamics state of serotonin under fearful state in mature FAE animals. These results suggest that FAE induces abnormalities of central nerves system via reduction of serotonergic function, mainly meditated by serotonin 1A receptor during period of brain development and prolonged abnormality of 5-HTergic function lead to anxiety-like behavior in mature FAE animals.
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会议论文
Can ipsapirone, a serotonin 1A receptor agonist, mitigate a developmental defect of the serotonergic system caused by prenatal exposure to ethanol?
伊沙匹隆（一种 5-羟色胺 1A 受体激动剂）能否减轻因产前接触乙醇而导致的 5-羟色胺能系统发育缺陷？
伊沙匹隆（一种 5-羟色胺 1A 受体激动剂）能否减轻因产前接触乙醇而导致的 5-羟色胺能系统发育缺陷？
DOI：
10.1111/j.1741-4520.2011.00340.x
发表时间：
2011
期刊：
Congenital anomalies
影响因子：
1.3
作者：
[Kanai T, Sakata-Haga H, Ohta K, Fukui Y]
通讯作者：
Fukui Y
Relation between abnormalities of serotonergic neurons and anxiety-related behaviors on prenatally ethanol-exposed rats
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批准号：20790766
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.66万
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财政年份：2008
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负责人：OHTA Kenichi
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依托单位：
Study on state- regulated prostitution in Japanese modern times
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批准号：11610359
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.43万
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财政年份：1999
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负责人：OHTA Kenichi
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依托单位：
海外基金