The local gene transfer for prevention of deep vein thrombosis
The local gene transfer for prevention of deep vein thrombosis
批准号:
20790901
负责人:
FURUKOUJI Eiji
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
抗凝是深静脉血栓形成的常用治疗方法。但过度或自发性出血可能是抗凝的副作用。本研究旨在探讨vWF-CP对腺病毒介导的静脉壁基因转移后的血小板聚集和血栓形成是否有抑制作用。结论:大鼠下腔静脉局部表达vWF-CP可预防静脉血栓形成。
英文摘要
Anticoagulation is the usual treatment for deep vein thrombosis. But excessive or spontaneous bleeding may be a side effect of anticoagulation. The present study examines whether vWF-CP suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to venous wall. Conclusion; The local expression of vWF-CP in rat inferior vena cava might prevent venous thrombosis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular-targeted therapy of venous thromboembolism
-
批准号:22791206
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.41万
-
财政年份:2010
-
负责人:FURUKOUJI Eiji
-
依托单位:
海外基金