BRM cocktail treatment using PSK and OK432 significantly up-regulates the migration activity in human dendritic cells without losing effective CTL induction

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Dendritic cells (DCs) based cancer immunotherapies are widely applicable for many kinds of human cancers; however, patient outcomes are still not acceptable. One of the major factors for successful DCs immunotherapy is thought to be the maintenance of the migratory activity of matured DCs. In the present study we evaluated the effectiveness of protein bound polysaccharide PSK on OK432-activated DCs, in terms of maturation, migration and induction of cytotoxic T lymphocytes. OK432 treated DCs induced higher level of cytotoxic activity with poor migration ability. When DCs were treated with both OK432 and PSK, migration ability of the DCs were significantly high as compared to OK432 alone preserving the beneficial effect of OK432 treatment. Biological Response Modifier cocktail treatment with OK432 and PSK induced high level of migration activity in activated DCs, suggesting a potential protocol for more effective DC immunotherapy for cancer.