Development of new cellular and gene therapy for liver cirrhosis

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In a cirrhotic liver, the hepatic functional reserve are impaired, therefore administration of hepatectomy are limited. Moreover, in order to elongate the survival outcome, therapeutic strategy against cirrhosis is needed. In this study, we demonstrated the administration of the hepatocyte growth factor (HGF) which were recognized as a promoter of cellular proliferation and as an anti-apoptotic or anti-fibrotic factor for injured tissue to drug inducing cirrhosis model and hepatectomy model and revealed improvement of fibrotic status and survival outcome after hepatectomy.