Development of new cellular and gene therapy for liver cirrhosis

肝硬化新细胞和基因疗法的开发

• 批准号: 20790936
• 负责人: UENO Masaki
• 金额: $ 1.41万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790936/
• 关键词: 再生医学; 肝硬変; 遺伝子治療; 細胞治療; Hepatocyte growth factor; 肝再生; heoatocyte growth factor; hepatocyte growth factor

In a cirrhotic liver, the hepatic functional reserve are impaired, therefore administration of hepatectomy are limited. Moreover, in order to elongate the survival outcome, therapeutic strategy against cirrhosis is needed. In this study, we demonstrated the administration of the hepatocyte growth factor (HGF) which were recognized as a promoter of cellular proliferation and as an anti-apoptotic or anti-fibrotic factor for injured tissue to drug inducing cirrhosis model and hepatectomy model and revealed improvement of fibrotic status and survival outcome after hepatectomy.

在肝硬化肝脏中，肝功能储备受损，因此肝切除术受到限制。此外，为了延长生存结果，需要针对肝硬化的治疗策略。在这项研究中，我们证明了肝细胞生长因子（HGF）的给药，该因子被公认为是细胞增殖的启动子，作为损伤组织的抗凋亡或抗纤维化因子，以诱导Cirrhosis模型和肝切除术模型，并揭示了纤维化状态和生存后的改善。

项目成果

Assessment of liver function for successful hepatectomy in patients with hepatocellular carcinoma with impaired hepatic function.

肝功能受损的肝细胞癌患者成功肝切除术的肝功能评估。

• 发表时间: 2008
• 期刊: J Hepatobiliary Pancreat Surg. 15
• 作者: Uchiyama K;et al.
• 通讯作者: et al.

当科における腹腔鏡補助下肝切除の工夫

我科腹腔镜辅助肝切除术的改进

• 发表时间: 2010
• 作者: Uchiyama K;et.al.;清水由紀子;上野昌樹
• 通讯作者: 上野昌樹

肝細胞癌の右葉切除術における新たな肝切除術後経過予測-ROC解析を用いた有用な線維化マーカーの抽出-

肝细胞癌右叶切除术后病程的新预测 - 使用 ROC 分析提取有用的纤维化标志物 -

• 发表时间: 2008
• 作者: Uchiyama K;et.al.;清水由紀子;上野昌樹;神奈木真理;上野昌樹;神奈木真理;上野昌樹;原嶋奈々江;上野昌樹
• 通讯作者: 上野昌樹

Half clamping of the infrahepatic inferior vena cava reduces bleeding during a hepatectomy by decresing the central venous pressure

半夹闭肝下下腔静脉可降低中心静脉压，从而减少肝切除术期间的出血

• 发表时间: 2009
• 期刊: Langenbecks Arch Surg 394
• 作者: Uchiyama;et.al.
• 通讯作者: et.al.

肝細胞癌(HCC)に対するHr2以上の肝切除における新たな術後合併症予測式の確立

建立 Hr2 或以上肝细胞癌 (HCC) 肝切除术术后并发症预测新公式

• 发表时间: 2009
• 作者: Uchiyama K;et.al.;清水由紀子;上野昌樹;神奈木真理;上野昌樹
• 通讯作者: 上野昌樹