Mechanism of compensatory neural network formation after brain injury
Mechanism of compensatory neural network formation after brain injury
批准号:
21700381
负责人:
UENO Masaki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
导致初始行为缺陷的脑损伤通常随后是自发的功能恢复。在目前的研究中,我们发现,重组的残余神经网络是至关重要的自发恢复运动功能脑损伤后的小鼠。此外,我们确定了几个关键信号(BDNF-TrkB,GABA,EphA 4-EphrinB 3,MAG/Nogo/OMgp-PirB),这些信号修饰了这种新的网络形成。
英文摘要
Brain injury that results in an initial behavioral deficit is frequently followed by spontaneous functional recovery. In the present study, we showed that reorganization of the remnant neural network was crucial for spontaneous recovery of motor function following brain injury in mice. Furthermore, we identified several key signals (BDNF-TrkB, GABA, EphA4-EphrinB3, MAG/Nogo/OMgp-PirB) that modify this new network formation.
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新生児脳におけるミクログリアによる神経細胞への生存促進作用
小胶质细胞对新生儿脑神经元的存活促进作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[上野将紀, 山下俊英]
通讯作者:
山下俊英
Olfactory mucosa transplantation following spinal cord injury improves voiding efficiency by suppressing detrusor sphincter dyssynergia in rats.
脊髓损伤后的嗅粘膜移植通过抑制大鼠逼尿肌括约肌协同失调来提高排尿效率。
DOI:
--
发表时间:
2010
期刊:
J Urol. 184(2)
影响因子:
--
作者:
[Nakayama J, Takao T, Kiuchi H, Yamamoto K, Fukuhara S, MiyagawaY, Aoki M, Iwatsuki K, Yoshimine T, Ueno M, Yamashita T, Nonomura N, Tsujimura A, Okuyama A.]
通讯作者:
Okuyama A.
Intraspinal rewiring of the corticospinal tract compensates lost function after brain injury.
皮质脊髓束的椎内重新布线可补偿脑损伤后丧失的功能。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Omoto S, Ueno M, Mochio S, Takai T, Yamashita T.]
通讯作者:
Yamashita T.
Intrinsic regenerative mechanisms of central nervous system neurons.
中枢神经系统神经元的内在再生机制。
DOI:
--
发表时间:
2009
期刊:
Bioscience Trend 3
影响因子:
--
作者:
[Muramatsu R., Ueno M., Yamashita T.]
通讯作者:
Yamashita T.
Compensatory neural network formation after cortical brain injury.
皮质脑损伤后代偿性神经网络的形成。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ueno M, Yamashita T.]
通讯作者:
Yamashita T.
共 22 条
Exploratory research of driver gene mutation and drug sensitivity-related genes expression changes in hepatocellular carcinoma
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财政年份:2008
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依托单位:
Combined therapy using TS-suppressing vector and 5-FU
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项目类别:Grant-in-Aid for Scientific Research (C)
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负责人:UENO Masaki
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依托单位:
海外基金