Development of new therapies for vascular dementia

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The expression of osteopontin, CD36, and LDL receptor (LDLR) was turned out to be increased in vessels showing blood-brain barrier (BBB) dysfunction. We could productsynthetic peptides of osteopontin, an antibody for osteopontin, virus vector expressing osteopontin. The expression of CD36 was turned out to be increased in the vessels showing BBB dysfunction in brains of hypertensive rats and senescence accelerated mice. Drugs inducing the reduction of CD36 or LDLR expression may be useful for the therapy against vascular dementia. In addition, angiotensin receptor blockers (ARBs) reduced vascular damage including the BBB damage, suggesting that the usage of ARBs with osteopontin may be effective for the therapy against vascular dementia.