Development of new therapies for vascular dementia

血管性痴呆新疗法的开发

• 批准号: 22590958
• 负责人: UENO Masaki
• 金额: $ 2.91万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590958/
• 关键词: 臨床神経形態学; 血管性認知症; オステオポンチン; CD36; 血管脳関門; Glut5; 血液脳関門

The expression of osteopontin, CD36, and LDL receptor (LDLR) was turned out to be increased in vessels showing blood-brain barrier (BBB) dysfunction. We could productsynthetic peptides of osteopontin, an antibody for osteopontin, virus vector expressing osteopontin. The expression of CD36 was turned out to be increased in the vessels showing BBB dysfunction in brains of hypertensive rats and senescence accelerated mice. Drugs inducing the reduction of CD36 or LDLR expression may be useful for the therapy against vascular dementia. In addition, angiotensin receptor blockers (ARBs) reduced vascular damage including the BBB damage, suggesting that the usage of ARBs with osteopontin may be effective for the therapy against vascular dementia.

血脑屏障 (BBB) 功能障碍的血管中骨桥蛋白、CD36 和 LDL 受体 (LDLR) 的表达增加。我们可以生产骨桥蛋白的合成肽、骨桥蛋白的抗体、表达骨桥蛋白的病毒载体。结果表明，高血压大鼠和衰老加速小鼠大脑中 BBB 功能障碍的血管中 CD36 的表达增加。诱导 CD36 或 LDLR 表达减少的药物可能有助于治疗血管性痴呆。此外，血管紧张素受体阻滞剂（ARB）可减少血管损伤，包括血脑屏障损伤，表明ARB与骨桥蛋白联合使用可能有效治疗血管性痴呆。

项目成果

The mechanism of blood-brain barrier dysfunction in vascular dementia.

血管性痴呆血脑屏障功能障碍的机制。

• 发表时间: 2011
• 作者: 上野正樹;池田研二;阪本晴彦;今井富裕;Ueno M.
• 通讯作者: Ueno M.

Angiotensin II induces human astrocyte senescence through reactive oxygen species production

• DOI: 10.1038/hr.2010.269
• 发表时间: 2011-04-01
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Liu, Gang;Hosomi, Naohisa;Nishiyama, Akira
• 通讯作者: Nishiyama, Akira

血液脳関門障害血管におけるCD36の発現について

CD36在血脑屏障受损血管中的表达

• 发表时间: 2011
• 作者: 上野正樹;池田研二;阪本晴彦;今井富裕;Ueno M.;今井富裕;上野正樹;Tomihiro Imai;上野正樹
• 通讯作者: 上野正樹

Transporters in the blood-brain barrier

血脑屏障中的转运蛋白

• 发表时间: 2011
• 作者: Ueno M;Nakagawa T;Sakamoto H.
• 通讯作者: Sakamoto H.

The optimal timing of antihypertensive medication administration for morning hypertension in patients with cerebral infarction

• DOI: 10.1038/hr.2012.25
• 发表时间: 2012-07-01
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Hosomi, Naohisa;Sueda, Yoshimasa;Matsumoto, Masayasu
• 通讯作者: Matsumoto, Masayasu