Expression and localization of keratinocyte growth factor receptor (KGFR) in esophageal cancer and molecular target thrapy

近年来分子靶点药物的研究进展显著，与生长因子受体相关的药物在临床上得到应用，其有效性得到证实。因此，我们认为我们可以将这些治疗应用于相对发展的食管癌分子靶向治疗领域，并针对角化细胞生长因子受体（KGFR）在食管癌细胞增殖和血管生成中发挥的重要作用。研究KGFR是否与食管癌的增殖有关，是否可以通过抑制KGFR来预防食管癌的生长，并探讨其作为分子靶向治疗的前景。

The progress of the recent molecular target drug is remarkable, and the medicine associated with the growth factor receptor is applied clinically, and those effectiveness is confirmed. Therefore we thought that we could apply these treatment to even relatively developing esophageal cancer in the field of molecular target therapy and aimed at a role of keratinocyte growth factor receptor (KGFR) which played role that was important to proliferation of cells and angiogenesis in esophageal cancer. Progressed a study whether KGFR was associated with a proliferation of esophageal cancer whether we might prevent growth of esophageal cancer by inhibiting KGFR and examined it about the future as the molecular target therapy.