Expression and localization of keratinocyte growth factor receptor (KGFR) in esophageal cancer and molecular target thrapy

最近的分子靶向药物进展显著，与生长因子受体相关的药物已应用于临床，并证实了其有效性。因此，我们认为在分子靶向治疗领域甚至可以将这些治疗应用于相对发展的食道癌，并针对角质形成细胞生长因子受体(KGFR)在食道癌的细胞增殖和血管生成中所起的重要作用。研究了KGFR是否与食道癌的增殖有关，是否可以通过抑制KGFR来预防食道癌的生长，并对其作为分子靶向治疗的未来进行了探讨。

The progress of the recent molecular target drug is remarkable, and the medicine associated with the growth factor receptor is applied clinically, and those effectiveness is confirmed. Therefore we thought that we could apply these treatment to even relatively developing esophageal cancer in the field of molecular target therapy and aimed at a role of keratinocyte growth factor receptor (KGFR) which played role that was important to proliferation of cells and angiogenesis in esophageal cancer. Progressed a study whether KGFR was associated with a proliferation of esophageal cancer whether we might prevent growth of esophageal cancer by inhibiting KGFR and examined it about the future as the molecular target therapy.