Identification of endogenous stem cells of the intervertebral disc in degeneration and treatment applications
Identification of endogenous stem cells of the intervertebral disc in degeneration and treatment applications
批准号:
20791056
负责人:
SAKAI Daisuke
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Heterogeneity of nucleus pulposus cells was revealed in various animal species including human. Endogenous stem/progenitor cells were identified in the intervertebral disc tissue. Its immaturity correlated negatively with age in humans showing that number of endogenous stem cell populations in the inetervertebral disc decrease with aging. Exogenous stem cells did not supply cells to the degenerated intervertebral disc showing that in the inetervertebral disc, exogenous mobilization of cells is extremely difficult. These facts rationalize the idea of supplying cells through external access.
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Activation of TonEBP by calcium controls {beta}1, 3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.
钙激活 TonEBP 可控制 {β}1, 3-葡萄糖醛酸基转移酶-I 的表达,这是椎间盘细胞中糖胺聚糖合成的关键调节因子。
DOI:
--
发表时间:
2009
期刊:
J Biol Chem. 284(15)
影响因子:
--
作者:
[Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV]
通讯作者:
Risbud MV
細胞レベルからの椎間板再生-細胞移植療法のその先に-
细胞水平的椎间盘再生 - 超越细胞移植疗法 -
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Hiyama, Akihiko, 酒井大輔]
通讯作者:
酒井大輔
Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
钙激活 TonEBP 可控制 {β}1,3-葡萄糖醛酸转移酶-I 的表达,这是椎间盘细胞中糖胺聚糖合成的关键调节因子
DOI:
--
发表时间:
2009
期刊:
Journal of Biological Chemistry 284
影响因子:
--
作者:
[Hiyama, Akihiko]
通讯作者:
Akihiko
DOI:
10.1097/brs.0b013e31816b4685
发表时间:
2008-04-15
期刊:
SPINE
影响因子:
3
作者:
[Katsuno, Raijiro, Hasegawa, Toru, Mochida, Joji]
通讯作者:
Mochida, Joji
DOI:
10.1002/jor.20584
发表时间:
2008-05-01
期刊:
JOURNAL OF ORTHOPAEDIC RESEARCH
影响因子:
2.8
作者:
[Hiyama, Akihiko, Mochida, Joji, Sakai, Daisuke]
通讯作者:
Sakai, Daisuke
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