Identification of endogenous stem cells of the intervertebral disc in degeneration and treatment applications

椎间盘内源性干细胞在退变和治疗应用中的鉴定

基本信息

  • 批准号:
    20791056
  • 负责人:
  • 金额:
    $ 2.75万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 财政年份:
    2008
  • 资助国家:
    日本
  • 起止时间:
    2008 至 2009
  • 项目状态:
    已结题

项目摘要

Heterogeneity of nucleus pulposus cells was revealed in various animal species including human. Endogenous stem/progenitor cells were identified in the intervertebral disc tissue. Its immaturity correlated negatively with age in humans showing that number of endogenous stem cell populations in the inetervertebral disc decrease with aging. Exogenous stem cells did not supply cells to the degenerated intervertebral disc showing that in the inetervertebral disc, exogenous mobilization of cells is extremely difficult. These facts rationalize the idea of supplying cells through external access.
髓核细胞在包括人类在内的各种动物中都表现出异质性。在间盘组织中可鉴定出内源性干/祖细胞。在人类中,其未成熟度与年龄呈负相关,表明椎间盘内内源性干细胞群体的数量随着年龄的增长而减少。外源性干细胞不能为退变的间盘提供细胞,说明在间盘中,外源性细胞的动员是极其困难的。这些事实使通过外部访问提供细胞的想法变得合理。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Activation of TonEBP by calcium controls {beta}1, 3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.
钙激活 TonEBP 可控制 {β}1, 3-葡萄糖醛酸基转移酶-I 的表达,这是椎间盘细胞中糖胺聚糖合成的关键调节因子。
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hiyama A;Gajghate S;Sakai D;Mochida J;Shapiro IM;Risbud MV
  • 通讯作者:
    Risbud MV
細胞レベルからの椎間板再生-細胞移植療法のその先に-
细胞水平的椎间盘再生 - 超越细胞移植疗法 -
  • DOI:
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hiyama;Akihiko;酒井大輔
  • 通讯作者:
    酒井大輔
Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
钙激活 TonEBP 可控制 {β}1,3-葡萄糖醛酸转移酶-I 的表达,这是椎间盘细胞中糖胺聚糖合成的关键调节因子
Age-related effects of cocultured rat nucleus pulposus cells and macrophages on nitric oxide production and cytokine imbalance
  • DOI:
    10.1097/brs.0b013e31816b4685
  • 发表时间:
    2008-04-15
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Katsuno, Raijiro;Hasegawa, Toru;Mochida, Joji
  • 通讯作者:
    Mochida, Joji
Transplantation of mesenchymal stem cells in a canine disc degeneration model
  • DOI:
    10.1002/jor.20584
  • 发表时间:
    2008-05-01
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Hiyama, Akihiko;Mochida, Joji;Sakai, Daisuke
  • 通讯作者:
    Sakai, Daisuke
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SAKAI Daisuke其他文献

SAKAI Daisuke的其他文献

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{{ truncateString('SAKAI Daisuke', 18)}}的其他基金

Elucidation of the molecular mechanism of interneuron development via hypoxia signaling
通过缺氧信号阐明中间神经元发育的分子机制
  • 批准号:
    19K06680
  • 财政年份:
    2019
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Realization of precision medicine for cancer chemotherapy
实现癌症化疗精准医疗
  • 批准号:
    18K08617
  • 财政年份:
    2018
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A Comprehensive Study of the Emperor's Sovereignty in Pre-war Showa Era
战前昭和时代天皇主权综合考察
  • 批准号:
    17H06684
  • 财政年份:
    2017
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology
通过计算机药物发生和 iPS 技术实现椎间盘再生和髓核祖细胞的转录控制
  • 批准号:
    16H05456
  • 财政年份:
    2016
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Identification of new chemical compound to induce pancreatic beta-cells
诱导胰腺β细胞的新化合物的鉴定
  • 批准号:
    26670603
  • 财政年份:
    2014
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Analysis of appropriate cell source for efficient annulus fibrosis regeneration
分析有效纤维环再生的适当细胞来源
  • 批准号:
    24592213
  • 财政年份:
    2012
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identifying the origin and niche environment of nucleus pulposus progenitor cells of the intervertebral disc and its therapeutic applications
椎间盘髓核祖细胞的起源和生态位环境的识别及其治疗应用
  • 批准号:
    22791406
  • 财政年份:
    2010
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Development of ultra-low optical loss functional glass elements using corona charging treatment
利用电晕充电处理开发超低光学损耗功能玻璃元件
  • 批准号:
    21760572
  • 财政年份:
    2009
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)

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    10225396
  • 财政年份:
    2019
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    $ 2.75万
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