Promoter hypermethylation and microsatellite instability in patients with head and neck squamous cell carcinoma with other primary sites

其他原发部位头颈鳞状细胞癌患者的启动子高甲基化和微卫星不稳定性

• 批准号: 20791216
• 负责人: NAKAMURA Aki
• 金额: $ 2.75万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791216/
• 关键词: 頭頸部癌; 重複癌; 異常メチル化; microsatellite instability; 異常メチル

In cultured cells from head and neck cancer, hypermethylation was detected at DAP-K in 28.6%, at MGMT in 28.6%, and at hMLH1 in 14.3%. These frequencies are similar to those reported in other studies. This findings suggest that hypermethylation of several tumor-associated genes plays an important role in tumorgenesis of head and neck cancer. The proportion of high-frequency MSI patients was higher in cases with multiple primary cancers than in those without them (p=0.0310). MSI thus appears to be a candidate biomarker for prediction the development of secondary cancer in head and neck cancer patients.

在培养的头颈癌细胞中，DAP-K、MGMT和hMLH1高甲基化的发生率分别为28.6%、28.6%和14.3%。这些频率与其他研究报告的频率相似。这一发现表明，几个肿瘤相关基因的高甲基化在头颈部癌的发生中起着重要作用。多原发癌患者中高频率微卫星感染的比例高于非多原发癌患者(p=0.0310)。因此，MSI似乎是预测头颈癌患者继发性癌症发展的一个候选生物标志物。