Analysis of molecular mechanisms in endogenous oxidative stress response and inhibition of retinal degeneration

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Protein expressions were analyzed in retinal samples from dark- and bright light-reared rats by using proteomics techniques. The results suggested that groups of proteins from several functional categories were involved in retinal protection in in vivo. Retinal levels of fatty acid were changed by a combination use of transgenic mice carrying n-3 fatty acid desaturase and modified fatty acid diet. The results of suggested that lower ratio of n6/n3 fatty acid in retina was related to the high susceptibility of retinal damage induced by intense light exposure.