Wavelength dependency of light-induced retinal protection and its molecular mechanisms.

光诱导视网膜保护的波长依赖性及其分子机制。

• 批准号: 22791661
• 负责人: TANITO Masaki
• 金额: $ 2.66万
• 依托单位: Shimane University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791661/
• 关键词: 網膜光障害; 網膜変性; 酸化ストレス; 抗酸化酵素; 光線波長; 網膜光傷害

Biological responses against various endogenous and exogenous stresses is primarily involved in the homeostatic mechanism in in vivo. This study was conducted to recognize molecular mechanisms of stress response against photooxidative stress in retinal cells/tissues and to accumulate knowledge that can be applied to retinal therapeutics for the future projects. In in vivo experiment using rats, by using the experimental settings established by me, I have explored action spectrums of retinal damage that induced by light exposure. In in vitro experiments, I have measured transmission spectrums of various types of intraocular lenses, and estimated retinal damage indexes that induced by light-pass through these lenses.

针对各种内源性和外源性应激的生物反应主要涉及体内稳态机制。进行这项研究的目的是认识视网膜细胞/组织中针对光氧化应激的应激反应的分子机制，并积累可应用于未来项目的视网膜治疗的知识。在大鼠体内实验中，通过使用我建立的实验设置，我探索了光照射引起的视网膜损伤的作用光谱。在体外实验中，我测量了各种类型人工晶状体的透射光谱，并估计了光线通过这些晶状体引起的视网膜损伤指数。

项目成果

Measurement of transmission spectrums and estimation of retinal blue-light irradiance values of currently available clear and yellow-tinted intraocular lenses

现有透明和黄色人工晶状体的透射光谱的测量和视网膜蓝光辐照度值的估计

• 发表时间: 2011
• 期刊: Japanese Journal of Ophthalmology
• 影响因子: 2.4
• 作者: Tanito M;Okuno T;Ishiba Y;Ohira A
• 通讯作者: Ohira A

Intravitreal injection of erythropeitin glycosylation analogs does not protect rod photoreceptor cells from light-induced damage

玻璃体内注射红细胞生成素糖基化类似物并不能保护视杆细胞免受光诱导的损伤

• 发表时间: 2012
• 期刊: Adv Exp Med Biol
• 作者: Tanito M;Li F;Anderson RE
• 通讯作者: Anderson RE

Retinal light damage induced by light exposure at different intervals in rats

不同时间间隔光照对大鼠视网膜光损伤的影响

• 发表时间: 2011
• 作者: Kaidzu S;Okuno T;Tanito M;Ohira A
• 通讯作者: Ohira A

Estimation for protective effects of clear and yellow-tinted intraocular lenses against sunlight-induced retinal damage

透明和黄色人工晶状体对阳光引起的视网膜损伤的保护作用评估

• 发表时间: 2010
• 作者: Tanito M;Okuno T;Ishiba Y;Ohira A
• 通讯作者: Ohira A