Group A streptococci translocates across epithelial barrier via intercellular junction cleavage

A组化脓性链球菌(GAS)是一种可引起局部化脓性感染和严重侵袭性疾病的人类病原体。气体的全身性传播是由细菌穿透咽部或受损皮肤的上皮屏障引起的。在这项研究中，我们的数据表明，链溶素S具有潜在的功能，通过降解上皮细胞间连接和宿主半胱氨酸蛋白酶Calain促进气体侵入更深层次的组织。

Group A Streptococcus pyogenes (GAS) is a human pathogen that causes local suppurative infections and severe invasive diseases. Systemic dissemination of GAS is initiated by bacterial penetration of the epithelial barrier of the pharynx or damaged skin. In this study, our data indicate a potential function of Streptolysin S that facilitates GAS invasion into deeper tissue via degradation of epithelial intercellular junctions in concert with the host cysteine protease calpain.