Elucidation of the salivary gland differentiation system which aimed at the salivary gland regenerative medicine

针对唾液腺再生医学的唾液腺分化系统的阐明

• 批准号: 20791533
• 负责人: IKARI Tatsuya
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791533/
• 关键词: 唾液腺; 再生医療; 幹細胞

We established a model three-imensional reconstruction of tissue culture cell separation from the submandibular gland primordia in this study. Rebuild their organization, were also admitted the expression of aquaporin as a marker or terminal. differentiation. This phenomenon, in the salivary gland tissue has shown that it contains a group of cells s should be called stem cells. Brachury is a transcription factor T-box is a gene required in mesoderm rormation, expression Brachury in the normal salivary glands, recognized the increased expression of a sudden on embryonic day 13. 5, after embryonic day 14. 5 the amount of its expression decreased proved that.

本研究建立了一种从下颌下腺原基分离组织培养细胞的三维重建模型。重建它们的组织时，也接纳水通道蛋白作为表达的标志或终点。分化这种现象表明，在唾液腺组织中含有一组细胞，应该称之为干细胞。Brachury是一种转录因子，T-box是中胚层形成所需的一个基因，Brachury在正常唾液腺中表达，在胚胎第13天表达突然增加。5、胚胎第14天后。5其表达量下降证明。