The effect of cathepsin E on orthodontic tooth movement

组织蛋白酶E对正畸牙齿移动的影响

• 批准号: 20791585
• 负责人: FUJIMURA Yuji
• 金额: $ 2.75万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791585/
• 关键词: 歯の移動; 破骨細胞; カテプシンE; 歯科矯正学; カテフシンE

The aim of this study was to investigate the effect of cathepsin E on TNF-α induced osteoclast differentiation and orthodontic tooth movement. The numbers of TNF-α induced osteoclasts were not significantly different between WT mice and cathepsin E knockout mice. Moreover, the distance of tooth movement was also not significantly different. These results suggest that cathepsin E have no effect on TNF-α induced osteoclast. Therefore it is not prevent orthodontic tooth movement.

本研究旨在探讨组织蛋白酶E对肿瘤坏死因子-α（TNF-α）诱导的破骨细胞分化及正畸牙移动的影响。TNF-α诱导的破骨细胞数量在WT小鼠和组织蛋白酶E敲除小鼠之间没有显著差异。此外，牙齿移动的距离也没有显着差异。提示组织蛋白酶E对TNF-α诱导的破骨细胞无影响。因此，它不会阻止正畸牙齿移动。

项目成果

Influence of bisphosphonates on orthodontic tooth movement in mice

• DOI: 10.1093/ejo/cjp068
• 发表时间: 2009-12-01
• 期刊: EUROPEAN JOURNAL OF ORTHODONTICS
• 影响因子: 2.6
• 作者: Fujimura, Yuji;Kitaura, Hideki;Yoshida, Noriaki
• 通讯作者: Yoshida, Noriaki

Effect of Bisphosphonates on Orthodontic Tooth Movement in Mice

双膦酸盐对小鼠正畸牙齿移动的影响

• 发表时间: 2009
• 作者: Yuji Fujimura;Hideki Kitaura;Masako Yoshimatsu;Haruka Kohara;Yukiko Morita;Toshiko Eguchi;Teruko Takano-Yamamoto;Noriaki Yoshida
• 通讯作者: Noriaki Yoshida