The dental trial and its molecular biological analysis to promotion of a move as reform study by multi-blood platelet plasma(PRP)

多血血小板血浆（PRP）推动改革研究的牙科试验及其分子生物学分析

• 批准号: 22792058
• 负责人: FUJIMURA Yuji
• 金额: $ 2.58万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792058/
• 关键词: 歯の移動; 歯学

I hear that the base of a dentistry orthodontic therapy applies and moves orthodontic force to a tooth, there is, and these foundations do not change. Although improvement in aesthetic appreciation nature, mitigation of sharp pain, simplification of cleaning, etc. are mentioned as a subject of a dentistry orthodontic therapy, shortening of the length of the treatment period to a treatment period is also one of the big subjects.The increase in efficiency of medical treatment is made by development of various materials, and research of mechanics in recent years, and shortening of a treatment period has come to be achieved. However, it cannot be said that the effect is still enough. In spite of the medical treatment for which the dentistry orthodontic therapy used the vital reaction, most approaches against the living body itself are not performed, but it is thought that shortening of the further treatment period is attained by controlling a vital reaction. It aims at the thing for which … More orthopedics and other dentistry fields are used and which obtain fundamental evidence using the experiment model of movement of the tooth of a mouse in multi-blood platelet plasma(PRP's) using and using the dental increase in efficiency of movement as figure wax in this research.The effect of PRP to dental movement was examined. It equipped with the closed coil spring of the upper incisor part alveolar bone of a mouse, and between the first molar of left-hand side, and carried out too the neighborhood movement of the first molar. From the heart of the syngeneic mouse, PRP collected blood and it centrifuged it. PRP which mixed the activator to the left-hand side first-molars cheek side subcutaneous part, and was activated to it at the time of a dental move start was injected. The silicone impression material for dentistries was used 12 days afterward, the upper jaw was impression taking, the first molar and the distance between the second molar were measured under the substance microscope, and it was considered as the dental amount of movements. In the PRP medication group and the PBS medication group(contrast group), the significant difference was not observed in the dental amount of movements.However, since optimal quantity of PRP is unknown, it seems first that examination is required about a optimal given dose from now on. Less

我听说牙科正畸治疗的基础应用和移动正畸力到牙齿，有，这些基础不会改变。虽然作为牙科正畸治疗的课题，提出了提高审美性、减轻尖锐疼痛、简化清洁等，但缩短治疗期的长度也是一个大课题。近年来，通过各种材料的开发和力学的研究，医疗效率得到提高，并且已经实现了治疗周期的缩短。但是，不能说效果还是足够的。尽管在牙科正畸治疗中使用了生命反应的医学治疗中，大多数针对活体本身的方法都没有执行，但是认为通过控制生命反应来实现进一步治疗时间的缩短。它的目标是 ...更多信息 本研究应用多血小板血浆（PRP’s）对小鼠牙齿移动的实验模型，以牙齿移动效率的提高为模型蜡，研究PRP对牙齿移动的影响，为临床应用提供了基础性依据。在小鼠的上切牙牙槽骨和左侧第一磨牙之间安装封闭式螺旋弹簧，实现第一磨牙的邻位移动。从同系小鼠的心脏采集PRP血液并离心，注射在左侧第一磨牙颊侧皮下部混合活化剂并在牙齿移动开始时对其活化的PRP。术后12d使用牙科用硅橡胶印模材料，取上颌印模，在实体显微镜下测量第一磨牙和第二磨牙间的距离，作为牙齿移动量。PRP治疗组和PBS治疗组（对照组）的牙齿移动量没有显著性差异，但PRP的最佳用量尚不清楚，因此，从现在开始，首先需要研究最佳给药剂量。减