Role of DNAM-1 (CD226) in rapid progressive glomerulonephritis

DNAM-1 (CD226) 在快速进展性肾小球肾炎中的作用

• 批准号: 20890030
• 负责人: KAI Hirayasu
• 金额: $ 2.11万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890030/
• 关键词: 急速進行性糸球体腎炎; DNAM-1(CD226); 抗糸球体基底膜抗体型糸球体腎炎; 半月体形成糸球体腎炎; DNAM-1遺伝子欠損マウス; anti-GBM型糸球体腎炎; DNAM-1; anti-GBM抗体

DNAM-1 (CD226) is an adhesion molecule expressed on the majority of NK cells, T cells, monocytes and platelets and physically and functionally associates with leukocyte function-associated antigen-1 (LFA-1). The poliovirus receptor (PVR) CD155 and its family member CD112 (PVR-related family-2 (PRR-2), also called as nectin-2) are ligands for human and mouse DNAM-1. We analyzed rapid progressive glomerulonephritis for wild type mouse and DNAM-1 (CD226) gene deficit mouse using antiglomerulus basement membrane antibody. We compared wild type mouse with the DNAM-1 gene deficit mouse, and the degree of the nephritis was showed weakly. The possibility that DNAM-1 related with the onset of the rapid progressive glomerulonephritis was suggested.

DNAM-1（CD 226）是在大多数NK细胞、T细胞、单核细胞和血小板上表达的粘附分子，并且在物理和功能上与白细胞功能相关抗原-1（LFA-1）相关。脊髓灰质炎病毒受体（PVR）CD 155及其家族成员CD 112（PVR相关家族-2（PRR-2），也称为nectin-2）是人和小鼠DNAM-1的配体。我们用抗肾小球基底膜抗体分析了野生型小鼠和DNAM-1（CD 226）基因缺陷小鼠的快速进行性肾小球肾炎。我们比较了野生型小鼠和DNAM-1基因缺陷小鼠，肾炎的程度显示较弱。提示DNAM-1可能与急进性肾小球肾炎的发病有关。