Role of DNAM-1 (CD226) in rapid progressive glomerulonephritis

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DNAM-1 (CD226) is an adhesion molecule expressed on the majority of NK cells, T cells, monocytes and platelets and physically and functionally associates with leukocyte function-associated antigen-1 (LFA-1). The poliovirus receptor (PVR) CD155 and its family member CD112 (PVR-related family-2 (PRR-2), also called as nectin-2) are ligands for human and mouse DNAM-1. We analyzed rapid progressive glomerulonephritis for wild type mouse and DNAM-1 (CD226) gene deficit mouse using antiglomerulus basement membrane antibody. We compared wild type mouse with the DNAM-1 gene deficit mouse, and the degree of the nephritis was showed weakly. The possibility that DNAM-1 related with the onset of the rapid progressive glomerulonephritis was suggested.