Identification and functional analysis of common genetic basis between type 1 diabetes and type 2 diabetes.

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The etiology of type 1 and type 2 diabetes is thought to be different. However, type 2 diabetes is often observed in the family of patients with type 1 diabetes, suggesting the common genetic basis among them. We identified the susceptibility genes to type 1 diabetes, as well as type 2 diabetes, in the Japanese individuals, and susceptibility loci to glucose tolerance, body weight, and insulin resistance in the mouse model of type 2 diabetes, in order to establish the screening panel of association study of common susceptibility genes to type 1 and type 2 diabetes. We reported a newly identified susceptibility gene to type 1 diabetes in both mice and human, and the association study with type 2 diabetes was performed.