弓状核GABAB系统能量平衡作用分析-猫眼课题宝

弓状核GABAB系统能量平衡作用分析

批准号：

20591093

负责人：

ARIMA Hiroshi

金额：

$3.24万

依托单位：

Nagoya University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2008

资助国家：

日本

项目状态：

已结题

起止时间：

2008 至 2010

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591093/

关键词：

肥満、視床下部 GABABレセプター GABAB 視床下部肥満レプチンインスリンエネルギーバランス GABA ノックアウトマウス

中文摘要

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英文摘要

We have made mice in which GABA_B receptor gene is knocked out exclusively in the POMC neurons using Cre-loxP system. The weight of epididymal white adipose tissues as well as body weight was increased in the knock-out mice compared to wild-type mice when they were fed a high-fat diet for 12 weeks from the age of 4 weeks. In addition, the levels of blood insulin and leptin were increased in the knockout mice compared to wild-type mice. Thus, our data suggest that GABA_B receptors in the POMC neurons play an important role in preventing the onset and progress of obesity.

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