Exploration for novel murine hematopoietic stem cells by the use of intra-bone marrow injection methods
Exploration for novel murine hematopoietic stem cells by the use of intra-bone marrow injection methods
批准号:
20591158
负责人:
SASAKI Yutaka
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Intra-bone marrow injection (IBMI) is a powerful method that enables highly efficient hematopoietic stem cell (HSC) engraftment in recipients' bone marrow. Using this method, novel HSCs that are not included in the c-kit^+Sca-1^+Lineage^-(KSL) compartment are explored. IBMI did not detect reproducibly the HSC activity in c-kit^-Sca^-1^+Linfraction, although in some rare cases, long-term hematopoietic reconstitution was observed in the fraction. Therefore, possibility remains that very rare HSCs exist in c-kit-fraction. On the other hand, c-kit^low fraction was proved to contain HSCs in low frequency. These HSCs were characterized.
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マウス造血幹細胞に対するSDF-1の作用機構の解析
SDF-1对小鼠造血干细胞作用机制分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[佐々木 豊, 松岡由和, 長谷 真, 薗田精昭]
通讯作者:
薗田精昭
Characterization of murine hematopoietic stem cell compartment based on the c-kit expression level
基于 c-kit 表达水平的小鼠造血干细胞区室表征
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[窪田哲朗, 福谷泰子, 南木敏宏, 宮坂伸之, 佐々木豊]
通讯作者:
佐々木豊
Marginal expression of CXCR4 on c-kit+Sca-1+Lineage- hematopoietic stem/progenitor cells.
CXCR4 在 c-kit Sca-1 谱系-造血干/祖细胞上的边缘表达。
DOI:
--
发表时间:
2009
期刊:
International Journal of Hematology. 90(5)
影响因子:
--
作者:
[Sasaki Y, Matsuoka Y, Hase M, Toyohara T, Murakami M, Takahashi M, Nakatsuka R, Uemura Y, Sonoda Y.]
通讯作者:
Sonoda Y.
c-kit発現レベルに基づくマウス骨髄造血幹細胞分画の検討
基于c-kit表达水平的小鼠骨髓造血干细胞分级检测
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[佐々木豊, 松岡由和, 中塚隆介, 植村靖史, 薗田精昭]
通讯作者:
薗田精昭
マウス骨髄由来Lineage-Sca-1^+c-kit^<low/->細胞の造血幹(前駆)細胞特性の解明
阐明小鼠骨髓来源的 Lineage-Sca-1^+c-kit^<low/> 细胞的造血干(祖)细胞特征
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[松岡由和, 佐々木豊, 中塚隆介, 植村靖史, 薗田精昭]
通讯作者:
薗田精昭
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Scholarly Activities of the Social Science Research Council to Construct the Interdisciplinary Knowledge of the Social Sciences
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批准号:19K01513
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:2019
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负责人:SASAKI Yutaka
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依托单位:
Investigation of c-ktlow murine hematopoietic stem cells for the role in aged animals
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批准号:25460483
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:SASAKI Yutaka
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依托单位:
NMR of extremely diluted impurity helium-3in quantum solid helium-4
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批准号:22654039
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.95万
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财政年份:2010
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负责人:SASAKI Yutaka
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依托单位:
Analysis of mechanisms underlying treatment-resistance ofhepatocelluar carcinoma in the point view of post-translationalmodification evaluated by proteomics
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批准号:21390230
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
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财政年份:2009
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负责人:SASAKI Yutaka
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依托单位:
Development of compounded type Kansei presumption/automated design system and a Kansei communication interface
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批准号:21780239
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2009
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负责人:SASAKI Yutaka
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依托单位:
Characterization of conductive ground using handheld loop-loop 3D electromagnetic method
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批准号:19560812
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2007
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负责人:SASAKI Yutaka
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依托单位:
2/3-dimension dynamic expression analysis and automatic design for food and environment using expression information
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批准号:19780195
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.36万
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财政年份:2007
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负责人:SASAKI Yutaka
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依托单位:
Analysis of molecular mechanisms underlying apoptosis resistance of hepatocellular carcinoma using proteomics
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批准号:18390219
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.98万
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财政年份:2006
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负责人:SASAKI Yutaka
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依托单位:
Improving the reliability of airborne and ground-based electromagnetic surveys by 3-D inversion (Its application to landslide investigations)
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批准号:15560702
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2003
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负责人:SASAKI Yutaka
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依托单位:
Magnetic Domain Structure and Anisotropic Thermal Conductivity
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批准号:15340117
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.69万
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财政年份:2003
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负责人:SASAKI Yutaka
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依托单位:
Analysis of survival signaling and its application for a new therapeutic strategy of cancers in gastro-intestinal tract and liver.
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批准号:14370182
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2002
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负责人:SASAKI Yutaka
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依托单位:
Magnetic anisotropy and structures of magnetic domain walls in antiferromagnetic solid Helium 3
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批准号:13640363
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.38万
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财政年份:2001
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负责人:SASAKI Yutaka
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依托单位:
Application of Ninjurin, a novel adhesion molecule, to diagnosis and therapeutics of primary hepatocellular carcinoma
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批准号:11670499
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1999
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负责人:SASAKI Yutaka
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依托单位:
Evaluation of effectiveness of 3-D resistivity surveys
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批准号:10650916
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1998
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负责人:SASAKI Yutaka
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依托单位:
Elucidation of polarization maintaining mechanism and Establishment of suppressing techniques of polarization fluctuation in fibers
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批准号:08650042
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.45万
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财政年份:1996
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负责人:SASAKI Yutaka
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依托单位:
Development of the software of three-dimensional interpretation for electromagnetic tomography
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批准号:07555332
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$1.98万
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财政年份:1995
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负责人:SASAKI Yutaka
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依托单位:
Basic study for gene therapy of human liver cancer in terms of regulating signal trnasduction pathway
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批准号:07670585
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:SASAKI Yutaka
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依托单位:
Development of Sectional Resistivity Image Analysis System and Its Application to Investigation of Fractured Rocks
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批准号:02650455
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.9万
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财政年份:1990
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负责人:SASAKI Yutaka
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依托单位:
海外基金