Functional analysis of novel effectors correlated with allergic diseases
Functional analysis of novel effectors correlated with allergic diseases
批准号:
20591188
负责人:
IZUHARA Kenji
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
关键词:
中文摘要
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英文摘要
It is known that IL-13, one of Th2-type cytokines, is important for the pathogenesis of bronchial asthma. In this study, we found the signals via Toll-like 4 receptor inhibit IL-13 production, how IL-13 interacts with its receptor, and IL-13 evokes allergic inflammation via pendrin, an anion transporter. We could show the detailed mechanism of how IL-13 causes bronchial asthma by these results.
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オーダーメイド医療を目指したアレルギー疾患における病因診断システムの確立
建立面向个性化医疗的过敏性疾病病因诊断体系
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[出原賢治, 白石裕士, 太田昭一郎, 増岡美穂, 内田賢, 太田昭一郎]
通讯作者:
太田昭一郎
アレルギー疾患免疫機序からみた一次予防のターゲットの可能性
从过敏性疾病免疫机制角度探讨一级预防的潜在靶点
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[松永和人, 柳澤悟, 市川朋宏, 上嶋千史, 赤松啓一郎, 平野綱彦, 中西正典, 山縣俊之, 南方良章, 一ノ瀬正和, 太田昭一郎, 太田昭一郎, 松永和人, 出原賢治]
通讯作者:
出原賢治
Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alphal chain by a silkworm-baculovirus system.
蚕杆状病毒系统表达人白细胞介素 4 受体 α 链和白细胞介素 13 受体 α 链的胞外区。
DOI:
--
发表时间:
2008
期刊:
Protein Expr. Purif. 60
影响因子:
--
作者:
[Kaneko Y., Suwa A., Hirakata M., Ikeda Y., Kuwana M., Honjo Eijiro]
通讯作者:
Honjo Eijiro
Expression of periostin in small peripheral lung adenocarcinoma Correlation with high-resolution CT findings, pathologic findings, and likelihood of tumor recurrence
骨膜素在周围型小肺腺癌中的表达与高分辨率 CT 结果、病理结果和肿瘤复发可能性的相关性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[K. Yoshimoto, C. Kumazawa, K. Tsuzaka, T. Abe, T. Takeuchi., Matsushita H, 永田真, 平形道人, Hoshino T, 高久洋太郎, 平形道人, Iwamoto R]
通讯作者:
Iwamoto R
関節リウマチ(第2版)-寛解を目指す治療の新時代-
类风湿性关节炎(第2版)-以缓解为目标的治疗新时代-
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[出原賢治, 他]
通讯作者:
他
共 56 条
Clarification of the functional roles of matrix proteins in the pathogenesis of allergic inflammation
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批准号:23591465
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
-
负责人:IZUHARA Kenji
-
依托单位:
Clarification of the underlying mechanism of allergic diseases targeting the signal pathways of the involved cytokines
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批准号:18604007
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.69万
-
财政年份:2006
-
负责人:IZUHARA Kenji
-
依托单位:
Clarification of the mechanism of allergic diseases based on the analyses of the mechanism of signal transduction of interleukin-4 and-13
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批准号:15591058
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
-
财政年份:2003
-
负责人:IZUHARA Kenji
-
依托单位:
Identification of atopy genes and analyses of their functions
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批准号:11670323
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:1999
-
负责人:IZUHARA Kenji
-
依托单位:
The Analyses of th Mechanism of IgE Production by Interleukin-4
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批准号:09670348
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.51万
-
财政年份:1997
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负责人:IZUHARA Kenji
-
依托单位:
Analysis of the Expression Mechanism of Immunoglobulin E by Interleukin-4
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批准号:07670385
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1995
-
负责人:IZUHARA Kenji
-
依托单位:
海外基金